ReviewCurrent neurology and neuroscience reports2012
Sodium and fluid management in acute brain injury.
Review in Current neurology and neuroscience reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 56 citations in OpenAlex.
- Association of fluid balance with 3-month outcomes in severe acute ischaemic stroke.Stroke and vascular neurology · 2026Article
- Risk factor analysis of hypertonic saline non-responders for the treatment of cerebral edema: a retrospective cohort study.International journal of clinical pharmacy · 2026Article
- Cerebral salt wasting syndrome in an elderly patient with traumatic brain injury: a case report.Frontiers in medicine · 2026Article
- Frequency of Dysnatremia in the First 24 Hours and Its Relationship with Mortality in Patients with Severe Brain Trauma : Dysnatremia and Head Trauma.Galen medical journal · 2025Article
- Point-of-care testing of hyponatremia and hypernatremia levels: An optoplasmonic biosensing approach.PloS one · 2025Article
- [Hyponatremia-workflow for intensive care physicians].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020Review
- Management of the Pediatric Neurocritical Care Patient.Seminars in neurology · 2016Review
- Atrial natriuretic factor: is it responsible for hyponatremia and natriuresis in neurosurgery?Revista Brasileira de terapia intensiva · 2016Observational
- Fluid management of the neurological patient: a concise review.Critical care (London, England) · 2016Review
- Severe Cranioencephalic Trauma: Prehospital Care, Surgical Management and Multimodal Monitoring.Bulletin of emergency and trauma · 2016Review
- Diabetes Insipidus after Traumatic Brain Injury.Journal of clinical medicine · 2015Review
- Neurological counterparts of hyponatremia: pathological mechanisms and clinical manifestations.Current neurology and neuroscience reports · 2015Review
- General intensive care for patients with traumatic brain injury: An update.Saudi journal of anaesthesia · 2014Article
- Treatment of endocrine disorders in the neuroscience intensive care unit.Current treatment options in neurology · 2014Article
- Clinical review: practical approach to hyponatraemia and hypernatraemia in critically ill patients.Critical care (London, England) · 2013Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sodium and fluid management in the brain injured patient directly impacts cerebral edema and cerebral perfusion pressure. Sodium is a major determinant of neuronal size and therefore hyponatremia is aggressively avoided, as hypoosmolar states result in cerebral edema. Negative fluid balance is often avoided because resultant drop in cerebral perfusion pressure can contribute to cerebral ischemia, further inducing secondary neuronal injury. Patients with brain injury are at risk for disorders of sodium and fluid balance (eg, syndrome of inappropriate antidiuresis, cerebral salt wasting, and diabetes insipidus). Knowledge of normal homeostatic and brain regulatory volume mechanisms is necessary to avoid inducing further neuronal or systemic injury while trying to correct sodium and fluid disorders in brain injured patients. Osmotherapy is a common part of managing cerebral edema in neurocritical care units, but more studies are needed to establish practice guidelines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.