ArticleUrological research2012
Studies on the in vitro and in vivo antiurolithic activity of Holarrhena antidysenterica.
Article in Urological research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Antiurolithic effects of medicinal plants: results of in vivo studies in rat models of calcium oxalate nephrolithiasis-a systematic review.Urolithiasis · 2021Pooled it
- Aldehyde Dehydrogenase 2 Gene Polymorphism and Alcohol Consumption Are Associated With Nephrolithiasis in a Chinese Population.Molecular genetics & genomic medicine · 2026Article
- Apoptosis, ferroptosis, necrosis, necroptosis and pyroptosis in the formation of calcium oxalate kidney stones.Urolithiasis · 2025Review
- Effects of Polyphenolic Extracts From Sumac, Pomegranate Peel, Indian Almond Leaves, Falsa, and Banana Bracts on Calcium Oxalate and Brushite Crystallization In Vitro.Chemistry & biodiversity · 2025Article
- Antiurolithic activity of vanillin in ethylene glycol-induced hyperoxaluric rat model.Urolithiasis · 2025Article
- Relationship between oxidative balance score and kidney stone prevalence in US adults.International urology and nephrology · 2024Article
- Expanded Therapeutic Applications ofCombinatorial chemistry & high throughput screening · 2024Review
- An insight investigation to the antiurolithic activity of Trachyspermum ammi using the in vitro and in vivo experiments.Urolithiasis · 2023Article
- Renal tubular epithelial cells treated with calcium oxalate up-regulate S100A8 and S100A9 expression in M1-polarized macrophages via interleukin 6.Iranian journal of basic medical sciences · 2023Article
- Antiurolithiatic Potential of Three Sri Lankan Medicinal Plants by the Inhibition of Nucleation, Growth, and Aggregation of Calcium Oxalate CrystalsTheScientificWorldJournal · 2022Article
- Evaluations of the curative efficacy of G. fruticosus solvent extracts in experimentally induced nephrolithiatic Wistar male rats.BMC complementary medicine and therapies · 2021Article
- Metabolic Diversity and Therapeutic Potential ofBiomolecules · 2020Review
- Effect ofIranian journal of medical sciences · 2020Article
- Total flavonoids of Desmodium styracifolium attenuates the formation of hydroxy-L-proline-induced calcium oxalate urolithiasis in rats.Urolithiasis · 2018Article
- Green synthesis of silver nanoparticles using Holarrhena antidysenterica (L.) Wall.bark extract and their larvicidal activity against dengue and filariasis vectors.Parasitology research · 2018Article
- Inhibitory effect of an aqueous extract of Radix Paeoniae Alba on calcium oxalate nephrolithiasis in a rat model.Renal failure · 2017Article
- An Explanation of the Underlying Mechanisms for the In Vitro and In Vivo Antiurolithic Activity ofOxidative medicine and cellular longevity · 2016Article
- On the origin of calcium oxalate monohydrate papillary renal stones.Urolithiasis · 2015Article
- Evalution of antiurolithic activity of alcoholic extract of roots of cissampelos pareira in albino rats.Journal of clinical and diagnostic research : JCDR · 2014Article
- Molecular mechanisms involved in the protective effect of the chloroform extract of Selaginella lepidophylla (Hook. et Grev.) Spring in a lithiasic rat model.Urolithiasis · 2013Article
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
Holarrhena antidysenterica has a traditional use in the treatment of urolithiasis, therefore, its crude extract has been investigated for possible antiurolithic effect. The crude aqueous-methanolic extract of Holarrhena antidysenterica (Ha.Cr) was studied using the in vitro and in vivo methods. In the in vitro experiments, Ha.Cr demonstrated a concentration-dependent (0.25-4 mg/ml) inhibitory effect on the slope of aggregation. It decreased the size of crystals and transformed the calcium oxalate monohydrate (COM) to calcium oxalate dehydrate (COD) crystals, in calcium oxalate metastable solutions. It also showed concentration-dependent antioxidant effect against 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals and lipid peroxidation induced in rat kidney tissue homogenate. Ha.Cr (0.3 mg/ml) reduced (p < 0.05) the cell toxicity and LDH release in renal epithelial cells (MDCK) exposed to oxalate (0.5 mM) and COM (66 μg/cm(2)) crystals. In male Wistar rats, receiving 0.75 % ethylene glycol (EG) for 21 days along with 1 % ammonium chloride (AC) in drinking water, Ha.Cr treatment (30-100 mg/kg) prevented the toxic changes caused by lithogenic agents; EG and AC, like loss of body weight, polyurea, oxaluria, raised serum urea and creatinine levels and crystal deposition in kidneys compared to their respective controls. These data indicate that Holarrhena antidysenterica possesses antiurolithic activity, possibly mediated through the inhibition of CaOx crystal aggregation, antioxidant and renal epithelial cell protective activities and may provide base for designing future studies to establish its efficacy and safety for clinical use.
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