ArticleThe Journal of membrane biology2012
In vivo muscle electroporation threshold determination: realistic numerical models and in vivo experiments.
Article in The Journal of membrane biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 54 citations in OpenAlex.
- A Model for Reversible Electroporation to Deliver Drugs into Diseased Tissues.The Journal of membrane biology · 2024Article
- Differential Expression Analysis of Cutaneous Squamous Cell Carcinoma and Basal Cell Carcinoma Proteomic Profiles Sampled with Electroporation-Based Biopsy.JID innovations : skin science from molecules to population health · 2024Article
- Electroporation-Based Biopsy Treatment Planning with Numerical Models and Tissue Phantoms.Annals of biomedical engineering · 2024Article
- Invasive and non-invasive electrodes for successful drug and gene delivery in electroporation-based treatments.Frontiers in bioengineering and biotechnology · 2022Review
- Electrochemotherapy using thin-needle electrode improves recovery in feline nasal planum squamous cell carcinoma - a translational model.Cancer drug resistance (Alhambra, Calif.) · 2022Article
- An ultra-low-cost electroporator with microneedle electrodes (ePatch) for SARS-CoV-2 vaccination.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Short microsecond pulses achieve homogeneous electroporation of elongated biological cells irrespective of their orientation in electric field.Scientific reports · 2020Article
- Education on electrical phenomena involved in electroporation-based therapies and treatments: a blended learning approach.Biomedical engineering online · 2016Article
- Gene Electrotransfer: A Mechanistic Perspective.Current gene therapy · 2016Review
- Mathematical Models Describing Chinese Hamster Ovary Cell Death Due to Electroporation In Vitro.The Journal of membrane biology · 2015Article
- Electroporation in food processing and biorefinery.The Journal of membrane biology · 2014Review
- Eradication of multidrug-resistantTechnology · 2014Article
- Modeling of electric field distribution in tissues during electroporation.Biomedical engineering online · 2013Article
- Potentiation of electrochemotherapy by intramuscular IL-12 gene electrotransfer in murine sarcoma and carcinoma with different immunogenicity.Radiology and oncology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vivo electroporation is used as an effective technique for delivery of therapeutic agents such as chemotherapeutic drugs or DNA into target tissue cells for different biomedical purposes. In order to successfully electroporate a target tissue, it is essential to know the local electric field distribution produced by an application of electroporation voltage pulses. In this study three-dimensional finite element models were built in order to analyze local electric field distribution and corresponding tissue conductivity changes in rat muscle electroporated either transcutaneously or directly (i.e., two-plate electrodes were placed either on the skin or directly on the skeletal muscle after removing the skin). Numerical calculations of electroporation thresholds and conductivity changes in skin and muscle were validated with in vivo measurements. Our model of muscle with skin also confirms the in vivo findings of previous studies that electroporation "breaks" the skin barrier when the applied voltage is above 50 V.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.