ReviewTrends in genetics : TIG2012
Oxytricha as a modern analog of ancient genome evolution.
Review in Trends in genetics : TIG, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Universal paralogs provide a window into evolution before the last universal common ancestor.Cell genomics · 2026Review
- A new LUCApedia database for data-driven research on early evolutionary history.Bioinformatics advances · 2026Article
- The Evolutionary Transition of the RNA World to Obcells to Cellular-Based Life.Journal of molecular evolution · 2024Article
- Electron transport chains as a window into the earliest stages of evolution.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A consensus view of the proteome of the last universal common ancestor.Ecology and evolution · 2022Article
- The very early evolution of protein translocation across membranes.PLoS computational biology · 2021Article
- The Coevolution of Cellularity and Metabolism Following the Origin of Life.Journal of molecular evolution · 2020Article
- Combined Genome and Transcriptome Analyses of the Ciliate Schmidingerella arcuata (Spirotrichea) Reveal Patterns of DNA Elimination, Scrambling, and Inversion.Genome biology and evolution · 2020Article
- Emerging Frontiers in the Study of Molecular Evolution.Journal of molecular evolution · 2020Article
- What Is a Genome?PLoS genetics · 2016Review
- The TIM Barrel Architecture Facilitated the Early Evolution of Protein-Mediated Metabolism.Journal of molecular evolution · 2016Article
- Article
- Genome structure drives patterns of gene family evolution in ciliates, a case study using Chilodonella uncinata (Protista, Ciliophora, Phyllopharyngea).Evolution; international journal of organic evolution · 2014Article
- Review
- LUCApedia: a database for the study of ancient life.Nucleic acids research · 2013Article
- The enzymatic and metabolic capabilities of early life.PloS one · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Several independent lines of evidence suggest that the modern genetic system was preceded by the 'RNA world' in which RNA genes encoded RNA catalysts. Current gaps in our conceptual framework of early genetic systems make it difficult to imagine how a stable RNA genome may have functioned and how the transition to a DNA genome could have taken place. Here we use the single-celled ciliate, Oxytricha, as an analog to some of the genetic and genomic traits that may have been present in organisms before and during the establishment of a DNA genome. Oxytricha and its close relatives have a unique genome architecture involving two differentiated nuclei, one of which encodes the genome on small, linear nanochromosomes. While its unique genomic characteristics are relatively modern, some physiological processes related to the genomes and nuclei of Oxytricha may exemplify primitive states of the developing genetic system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.