ArticleGenes and immunity2012
High-throughput antibody sequencing reveals genetic evidence of global regulation of the naïve and memory repertoires that extends across individuals.
Article in Genes and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Engineering strategies and binding mechanisms of therapeutic anti-PD-1 antibodies approved by regulatory agencies globally.Frontiers in immunology · 2026Review
- Low-Level Expression of CD138 Marks Naturally Arising Anergic B Cells.Immune network · 2022Article
- Skewing of the antibody repertoire in cerebrospinal fluid B cells from healthy controls and patients with schizophrenia.Behavioural brain research · 2022Article
- Mutational patterns along different evolution paths of follicular lymphoma.Frontiers in oncology · 2022Article
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- The respiratory syncytial virus (RSV) prefusion F-protein functional antibody repertoire in adult healthy donors.EMBO molecular medicine · 2021Article
- The Future of Blood Testing Is the Immunome.Frontiers in immunology · 2021Article
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- High Frequency of Shared Clonotypes in Human T Cell Receptor Repertoires.Cell reports · 2020Article
- Deep Characterization of the Human Antibody Response to Natural Infection Using Longitudinal Immune Repertoire Sequencing.Molecular & cellular proteomics : MCP · 2020Article
- Differential Expression of IgM and IgD Discriminates Two Subpopulations of Human Circulating IgMFrontiers in immunology · 2020Article
- Immune repertoire fingerprinting by principal component analysis reveals shared features in subject groups with common exposures.BMC bioinformatics · 2019Article
- On being the right size: antibody repertoire formation in the mouse and human.Immunogenetics · 2018Review
- Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine Design.Frontiers in immunology · 2018Review
- Evidence for Shaping of Light Chain Repertoire by Structural Selection.Frontiers in immunology · 2018Article
- In-Depth Analysis of Human Neonatal and Adult IgM Antibody Repertoires.Frontiers in immunology · 2018Article
- Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing.PloS one · 2018Article
- A generalized quantitative antibody homeostasis model: antigen saturation, natural antibodies and a quantitative antibody network.Clinical & translational immunology · 2017Article
- Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation.Frontiers in immunology · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Vast diversity in the antibody repertoire is a key component of the adaptive immune response. This diversity is generated centrally through the assembly of variable, diversity and joining gene segments, and peripherally by somatic hypermutation and class-switch recombination. The peripheral diversification process is thought to only occur in response to antigenic stimulus, producing antigen-selected memory B cells. Surprisingly, analyses of the variable, diversity and joining gene segments have revealed that the naïve and memory subsets are composed of similar proportions of these elements. Lacking, however, is a more detailed study, analyzing the repertoires of naïve and memory subsets at the level of the complete V(D)J recombinant. This report presents a thorough examination of V(D)J recombinants in the human peripheral blood repertoire, revealing surprisingly large repertoire differences between circulating B-cell subsets and providing genetic evidence for global control of repertoire diversity in naïve and memory circulating B-cell subsets.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.