ArticleJournal of the International Neuropsychological Society : JINS2012
Effects of HIV and early life stress on amygdala morphometry and neurocognitive function.
Article in Journal of the International Neuropsychological Society : JINS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Effects of HIV and Adverse Childhood Experiences on Neurocognition.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Cross-sectional observational study evaluating social brain health in HIV using a research domain criteria-based approach: a protocol.BMJ open · 2026Article
- Limbic and whole-brain functional connectivity in non-substance abusers with human immunodeficiency virus (HIV).Journal of neurovirology · 2026Article
- Divergent structural and functional brain alterations in HIV-infected patients: a multimodal meta-analysis.Frontiers in neurology · 2025Review
- HIV Interacts with Posttraumatic Stress Disorder to Impact Fear Psychophysiology in Trauma-Exposed Black Women.Women's health reports (New Rochelle, N.Y.) · 2024Article
- Modularity-Constrained Dynamic Representation Learning for Interpretable Brain Disorder Analysis with Functional MRI.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2023Article
- Alexithymia Among People Living with HIV: A Scoping Review.AIDS and behavior · 2023Article
- Effects of clinical, comorbid, and social determinants of health on brain ageing in people with and without HIV: a retrospective case-control study.The lancet. HIV · 2023Article
- The Evolution of Assessing Central Nervous System Complications in Human Immunodeficiency Virus: Where Do We Go From Here?The Journal of infectious diseases · 2023Article
- Effects of Early-Life Adversities on Neuropsychiatric and Executive Functions in HIV-Positive Adults.Journal of the International Neuropsychological Society : JINS · 2023Article
- Synergistic effects of high early-life stress exposure and HIV infection on reaction time variability.Frontiers in psychology · 2023Article
- Neurodegeneration Within the Amygdala Is Differentially Induced by Opioid and HIV-1 Tat Exposure.Frontiers in neuroscience · 2022Article
- Mini-review: Elucidating the psychological, physical, and sex-based interactions between HIV infection and stress.Neuroscience letters · 2021Review
- HIV-Associated Structural and Functional Brain Alterations in Homosexual Males.Frontiers in neurology · 2021Article
- Neurobehavioral outcomes in young adults with perinatally acquired HIV.AIDS (London, England) · 2020Article
- The relationship between potentially traumatic or stressful events, HIV infection and neurocognitive impairment (NCI): a systematic review of observational epidemiological studies.European journal of psychotraumatology · 2020Review
- Effect of HIV and Interpersonal Trauma on Cortical Thickness, Cognition, and Daily Functioning.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Effects of trauma, economic hardship, and stress on neurocognition and everyday function in HIV.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019Article
- Incidence and Persistence of Depression Among Women Living with and Without HIV in South Africa: A Longitudinal Study.AIDS and behavior · 2018Article
- Resting-state connectivity and spontaneous activity of ventromedial prefrontal cortex predict depressive symptomology and peripheral inflammation in HIV.Journal of neurovirology · 2018Article
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Authors and funding
12 authors.
Funding
Abstract
Both HIV infection and high levels of early life stress (ELS) have been related to abnormalities in frontal-subcortical structures, yet the combined effects of HIV and ELS on brain structure and function have not been previously investigated. In this study we assessed 49 non-demented HIV-seropositive (HIV+) and 47 age-matched HIV-seronegative healthy control (HC) adults. Levels of ELS exposure were quantified and used to define four HIV-ELS groups: HC Low-ELS (N = 20); HC High-ELS (N = 27); HIV+ Low-ELS (N = 24); HIV+ High-ELS (N = 25). An automated segmentation tool measured volumes of brain structures known to show HIV-related or ELS-related effects; a brief neurocognitive battery was administered. A significant HIV-ELS interaction was observed for amygdala volumes, which was driven by enlargements in HIV+ High-ELS participants. The HIV+ High-ELS group also demonstrated significant reductions in psychomotor/processing speed compared with HC Low-ELS. Regression analyses in the HIV+ group revealed that amygdala enlargements were associated with higher ELS, lower nadir CD4 counts, and reduced psychomotor/processing speed. Our results suggest that HIV infection and high ELS interact to increase amygdala volume, which is associated with neurocognitive dysfunction in HIV+ patients. These findings highlight the lasting neuropathological influence of ELS and suggest that high ELS may be a significant risk factor for neurocognitive impairment in HIV-infected individuals.
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