ArticleBrain stimulation2013
High frequency stimulation can suppress globally seizures induced by 4-AP in the rat hippocampus: an acute in vivo study.
Article in Brain stimulation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Bradycardia is induced by hyperactivity of the vagus nerve and nucleus ambiguus during seizures propagating into the brainstem.Epilepsia open · 2025Article
- A Transformer-Based Framework With Data Augmentation for Robust Seizure Detection Across Invasive and Noninvasive Neural Recordings.CNS neuroscience & therapeutics · 2025Article
- Effects of acute hippocampal stimulation in the nonhuman primate penicillin model of temporal lobe seizures.Heliyon · 2024Article
- Regulating absence seizures by tri-phase delay stimulation applied to globus pallidus internal.Applied mathematics and mechanics · 2022Article
- Suppressing synchronous firing of epileptiform activity by high-frequency stimulation of afferent fibers in rat hippocampus.CNS neuroscience & therapeutics · 2021Article
- Neural mass modeling of slow-fast dynamics of seizure initiation and abortion.PLoS computational biology · 2020Article
- [A new algorithm for automatically detecting epileptiform spikes and its application in epilepsy models].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2017Article
- Prediction of the Seizure Suppression Effect by Electrical Stimulation via a Computational Modeling Approach.Frontiers in computational neuroscience · 2017Article
- Stimulus-induced Epileptic Spike-Wave Discharges in Thalamocortical Model with Disinhibition.Scientific reports · 2016Article
- Computational modeling of epileptiform activities in medial temporal lobe epilepsy combined with in vitro experiments.Journal of computational neuroscience · 2016Article
- Seizure reduction through interneuron-mediated entrainment using low frequency optical stimulation.Experimental neurology · 2015Article
- Fiber tract stimulation can reduce epileptiform activity in an in-vitro bilateral hippocampal slice preparation.Experimental neurology · 2013Article
- Seizure suppression by high frequency optogenetic stimulation using in vitro and in vivo animal models of epilepsy.Brain stimulationArticle
- Neurostimulation as a Putative Method for the Treatment of Drug-resistant Epilepsy in Patient and Animal Models of Epilepsy.Basic and clinical neuroscienceReview
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundHigh frequency stimulation (HFS) on the hippocampus can locally suppress epileptiform activity in-vitro and decrease seizure frequency in vivo. In-vitro HFS on the ventral commissural tract, a novel target, was shown to block the axonal conduction and suppress activity in the CA1 and CA3 neuron.
objectiveTo study the spatial extent of seizure suppression by HFS applied on the tract and focus site in an in vivo experiment.
methodsFive adult Sprague-Dawley rats were used for the study. Six electrodes were placed on the septal, middle, and temporal hippocampus bilaterally to simultaneously record seizure activity in the entire hippocampus. Seizure activity was induced by injecting 4-aminopyridine (4-AP) into the right middle part of the hippocampus. Following induction, HFS (100 Hz) was applied to the tract and the focus site at 100, 300 and 500 μA.
resultsThe induced seizure activity was dominated by two patterns, high frequency spiking and pseudo-periodic spikes. Either tract or focus site stimulation could generate suppression of only the pseudo-periodic spikes. The suppression rates were dependent on stimulation amplitude (P < 0.005, chi square test). However, HFS also caused conversion of the seizure pattern. The conversion rates increased with higher stimulation amplitudes and were higher with focus site stimulation (P < 0.01, Fisher's exact test).
conclusionsThe results of this study have two practical implications [1], both tract and focus site stimulation can produce global suppression of hippocampus and [2] the choice of stimulation parameters is critical in order to produce suppression, but not conversion, of seizure pattern.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.