Evidence map›Paper›PMID 22621853›Full record

ReviewCurrent opinion in microbiology2012

Role of host reticulon proteins in rearranging membranes for positive-strand RNA virus replication.

Arturo Diaz, Paul Ahlquist

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
6.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. The inhibition mechanism ofFrontiers in microbiology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Frontiers in immunology · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Arturo DiazInstitute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706, United States.
Paul Ahlquist
University of Wisconsin–Madison · US

Funding

GRADUATE TRAINING IN MOLECULAR BIOSCIENCEST32GM007215 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HULL, CHRISTINA M · 1985 to 2018
$22.5M
Virology Training ProgramT32AI078985 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI LAMBERT, PAUL F. · 2009 to 2018
$3.3M
GENE FUNCTIONS AND MOLECULAR GENETICS OF RNA VIRUSESR37GM035072 · NIGMS · UNIVERSITY OF WISCONSIN MADISON · PI AHLQUIST, PAUL G. · 1995 to 2004
$1.9M
GENE FUNCTIONS AND MOLECULAR GENETICS OF RNA VIRUSESR01GM035072 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI AHLQUIST, PAUL G. · 1985 to 2009
$1.6M
NIAID NIH HHS T32 AI078985NIGMS NIH HHS GM35072NIGMS NIH HHS R01 GM035072NIGMS NIH HHS R37 GM035072NIGMS NIH HHS T32 GM007215NIGMS NIH HHS T32 GM07215
6 · The paper itself

Abstract

Positive-strand RNA [(+)RNA] viruses are responsible for numerous human, animal, and plant diseases. Because of the limiting coding capacity of (+)RNA viruses, their replication requires a complex orchestration of interactions between the viral genome, viral proteins and exploited host factors. To replicate their genomic RNAs, (+)RNA viruses induce membrane rearrangements that create membrane-linked RNA replication compartments. Along with substantial advances on the ultrastructure of the membrane-bound RNA replication compartments, recent results have shed light into the role that host factors play in rearranging these membranes. This review focuses on recent insights that have driven a new understanding of the role that the membrane-shaping host reticulon homology domain proteins (RHPs) play in facilitating the replication of various (+)RNA viruses.

Indexed as

Virus ReplicationAnimalsEndoplasmic ReticulumGenome, ViralHumansIntracellular MembranesMembrane ProteinsRNA, ViralRNA VirusesViral ProteinsMembrane ProteinsRNA, ViralViral Proteins

Identifiers

PMID22621853
PMCPMC3670673
OpenAlexW2024531880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.