ArticleInternational wound journal2013
Wound healing by topical application of antioxidant iron chelators: kojic acid and deferiprone.
Article in International wound journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Kojic Acid as a Natural Hypopigmenting Agent: Biological Activities, Delivery Challenges, and Nanotechnology-Based Strategies.Pharmaceutics · 2026Review
- Synergistic Antimicrobial Effects of Melaleuca alternifolia Essential Oil and Kojic Acid Combinations.Current microbiology · 2025Article
- The emerging role and therapeutical implications of ferroptosis in wound healing.Burns & trauma · 2025Review
- Deferiprone-Gallium-Protoporphyrin Chitogel DecreasesMaterials (Basel, Switzerland) · 2024Article
- Eobania vermiculata whole-body muscle extract-loaded chitosan nanoparticles enhanced skin regeneration and decreased pro-inflammatory cytokines in vivo.Journal of nanobiotechnology · 2023Article
- Article
- Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment.Inflammation and regeneration · 2022Review
- Recent technological advances in the management of chronic wounds: A literature review.Health science reports · 2022Review
- Hepatoprotective Potential of Malaysian Medicinal Plants: A Review on Phytochemicals, Oxidative Stress, and Antioxidant Mechanisms.Molecules (Basel, Switzerland) · 2022Review
- The Unexplored Wound Healing Activity ofMolecules (Basel, Switzerland) · 2021Article
- The effect of deferoxamine injection on composite graft survival in rabbits.Annals of medicine and surgery (2012) · 2020Article
- Antibiotics Affect ROS Production and Fibroblast Migration in anFrontiers in cellular and infection microbiology · 2020Article
- Chemical Structure-Antioxidant Activity Relationship of Water-Based Enzymatic Polymerized Rutin and Its Wound Healing Potential.Polymers · 2019Article
- Deferiprone has anti-inflammatory properties and reduces fibroblast migration in vitro.Scientific reports · 2019Article
- African Herbal Remedies with Antioxidant Activity: A Potential Resource Base for Wound Treatment.Evidence-based complementary and alternative medicine : eCAM · 2018Review
- Safety and Efficacy of Topical Chitogel- Deferiprone-Gallium Protoporphyrin in Sheep Model.Frontiers in microbiology · 2018Article
- A Topical Hydrogel with Deferiprone and Gallium-Protoporphyrin Targets Bacterial Iron Metabolism and Has Antibiofilm Activity.Antimicrobial agents and chemotherapy · 2017Article
- Kojic acid-mediated damage responses induce mycelial regeneration in the basidiomycete Hypsizygus marmoreus.PloS one · 2017Article
- In vitro and in silico studies of the inhibitory effects of some novel kojic acid derivatives on tyrosinase enzyme.Iranian journal of basic medical sciences · 2016Article
- A novel function for kojic acid, a secondary metabolite from Aspergillus fungi, as antileishmanial agent.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kojic acid and deferiprone are iron chelators used for skin lightening and iron-overload treatment, respectively. As iron chelation and free radical scavenging are principal factors for wound healing, it was hypothesised that the local application of these compounds might accelerate wound healing in rats. Ointments of 3%, 6% and 9% of deferiprone and kojic acid were prepared and topical treatment was performed on in vivo wound models for 12 days twice in day for test and control groups. Topical treatment with 3%, 6% and 9% showed significant improvement in wound healing after 4 days (P < 0·001). Topical application of 3% and 6% deferiprone enhanced wound healing after 8 days (P < 0·026 and P < 0·001, respectively). Accelerated wound healing was seen using 3% and 6% deferiprone after 12 days (P = 0·003 and P < 0·001, respectively). DPPH scavenging assay was also performed to compare the antioxidant potencies of kojic acid and deferiprone. Deferiprone had more free radical scavenging power than kojic acid. Generally, deferiprone topical treatment, accelerated wound healing more than kojic acid because of its higher antioxidant and iron chelation abilities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.