ArticleJournal of biomedical semantics2012
The Ontology for Parasite Lifecycle (OPL): towards a consistent vocabulary of lifecycle stages in parasitic organisms.
Article in Journal of biomedical semantics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- VO: The Vaccine Ontology.Scientific data · 2026Article
- VO: The Vaccine Ontology.bioRxiv : the preprint server for biology · 2025Article
- A fourfold pathogen reference ontology suite.Journal of biomedical semantics · 2025Article
- A Fourfold Pathogen Reference Ontology Suite.ArXiv · 2025Article
- Ontological representation, modeling, and analysis of parasite vaccines.Journal of biomedical semantics · 2024Article
- The Protégé Project: A Look Back and a Look Forward.AI matters · 2015Article
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Authors and funding
11 authors.
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Abstract
backgroundGenome sequencing of many eukaryotic pathogens and the volume of data available on public resources have created a clear requirement for a consistent vocabulary to describe the range of developmental forms of parasites. Consistent labeling of experimental data and external data, in databases and the literature, is essential for integration, cross database comparison, and knowledge discovery. The primary objective of this work was to develop a dynamic and controlled vocabulary that can be used for various parasites. The paper describes the Ontology for Parasite Lifecycle (OPL) and discusses its application in parasite research.
resultsThe OPL is based on the Basic Formal Ontology (BFO) and follows the rules set by the OBO Foundry consortium. The first version of the OPL models complex life cycle stage details of a range of parasites, such as Trypanosoma sp., Leishmaniasp., Plasmodium sp., and Shicstosoma sp. In addition, the ontology also models necessary contextual details, such as host information, vector information, and anatomical locations. OPL is primarily designed to serve as a reference ontology for parasite life cycle stages that can be used for database annotation purposes and in the lab for data integration or information retrieval as exemplified in the application section below.
conclusionOPL is freely available at http://purl.obolibrary.org/obo/opl.owl and has been submitted to the BioPortal site of NCBO and to the OBO Foundry. We believe that database and phenotype annotations using OPL will help run fundamental queries on databases to know more about gene functions and to find intervention targets for various parasites. The OPL is under continuous development and new parasites and/or terms are being added.
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