ArticleClinical epigenetics2012
On the epigenetics of vascular regulation and disease.
Article in Clinical epigenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- Roles of different methylation modifications in cardiovascular disease.Frontiers of medicine · 2025Review
- The Role of Epigenetics in Myocardial Infarction: Mechanism, Biomarkers and Therapeutic Potential.Galen medical journal · 2024Review
- The association between DNA methylation of 6p21.33 and AHRR in blood and coronary heart disease in Chinese population.BMC cardiovascular disorders · 2022Article
- Article
- DNA Methylation Pattern of CALCA and CALCB in Extremely Premature Infants with Monochorionic Triplets after Single-Embryo Transfer.Oxidative medicine and cellular longevity · 2021Article
- Epigenetics and systemic sclerosis: An answer to disease onset and evolution?European journal of rheumatology · 2020Review
- Genetic and Epigenetic Mechanisms Underlying Vascular Smooth Muscle Cell Phenotypic Modulation in Abdominal Aortic Aneurysm.International journal of molecular sciences · 2020Review
- Differential methylation pattern in patients with coronary artery disease: pilot study.Molecular biology reports · 2019Article
- Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR.Frontiers in endocrinology · 2019Review
- Targeting vascular (endothelial) dysfunction.British journal of pharmacology · 2017Review
- An integrated approach to coronary heart disease diagnosis and clinical management.American journal of translational research · 2017Review
- Correlation between insulin-induced estrogen receptor methylation and atherosclerosis.Cardiovascular diabetology · 2016Article
- Epigenetic associations in relation to cardiovascular prevention and therapeutics.Clinical epigenetics · 2016Review
- Epigenetic modulation as a therapeutic approach for pulmonary arterial hypertension.Experimental & molecular medicine · 2015Review
- Epigenetic reprogramming in atherosclerosis.Current atherosclerosis reports · 2015Review
- Diverse forms of pulmonary hypertension remodel the arterial tree to a high shear phenotype.American journal of physiology. Heart and circulatory physiology · 2014Article
- Role of epigenetics in pulmonary hypertension.American journal of physiology. Cell physiology · 2014Review
- The pathophysiology of hypertension in patients with obesity.Nature reviews. Endocrinology · 2014Review
- NOS1 methylation and carotid artery intima-media thickness in children.Circulation. Cardiovascular genetics · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Consolidated knowledge is accumulating as to the role of epigenetic regulatory mechanisms in the physiology of vascular development and vascular tone as well as in the pathogenesis of cardiovascular disease. The modulation of gene expression through modification of the epigenome by structural changes of the chromatin architecture without alterations of the associated genomic DNA sequence is part of the cellular response to environmental changes. Such environmental conditions, which are finally being translated into adaptations of the cardiovascular system, also comprise pathological conditions such as atherosclerosis or myocardial infarction. This review summarizes recent findings on the epigenetics of vascular regulation and disease and presents nutritional and pharmacological approaches as novel epigenetic strategies in the prevention and treatment of cardiovascular disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.