ArticleInfluenza and other respiratory viruses2012
Viral load at diagnosis and influenza A H1N1 (2009) disease severity in children.
Article in Influenza and other respiratory viruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Influenza and other respiratory viruses: standardizing disease severity in surveillance and clinical trials.Expert review of anti-infective therapy · 2017Pooled it
- Viruses as Sole Causative Agents of Severe Acute Respiratory Tract Infections in Children.PloS one · 2016Trial
- Symptom propagation in respiratory pathogens of public health concern: a review of the evidence.Journal of the Royal Society, Interface · 2024Review
- A six-plex droplet digital RT-PCR assay for seasonal influenza virus typing, subtyping, and lineage determination.Influenza and other respiratory viruses · 2020Article
- Associations Between Relative Viral Load at Diagnosis and Influenza A Symptoms and Recovery.Open forum infectious diseases · 2020Article
- Viral Kinetics and Resistance Development in Children Treated with Neuraminidase Inhibitors: The Influenza Resistance Information Study (IRIS).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Influenza A(H1N1)pdm09 infection and viral load analysis in patients with different clinical presentations.Memorias do Instituto Oswaldo Cruz · 2020Article
- Predictors of influenza a molecular viral shedding in Hutterite communities.Influenza and other respiratory viruses · 2017Article
- Viral Infection in the Development and Progression of Pediatric Acute Respiratory Distress Syndrome.Frontiers in pediatrics · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess viral load at diagnosis (VLAD) as a biomarker of novel influenza disease severity, epidemiologic and clinical data of admitted patients <18 years old with Influenza A H1N1 (2009) infection and respiratory symptoms were prospectively collected in a single pediatric tertiary hospital, from weeks 30-51 of 2009. Seventy patients were included. VLAD in children who had symptoms for ≥ 5 days was an accurate parameter distinguishing the patients who required mechanical ventilation (MV) from those who did not required it (area under the ROC curve: 0.73; P=0.03). Having <4.5 log10 copies/ml with ≥ 5 days of symptoms was associated with a lower risk of requiring MV.
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