ArticleNutrition & metabolism2012
Thyroid stimulating hormone, independent of thyroid hormone, can elevate the serum total cholesterol level in patients with coronary heart disease: a cross-sectional design.
Article in Nutrition & metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Alteration of lipid profile in subclinical hypothyroidism: a meta-analysis.Medical science monitor : international medical journal of experimental and clinical research · 2014Pooled it
- The health status and the prevalence of metabolic disorders of adult endemic cretinism-An epidemiological study in China.Lipids in health and disease · 2025Article
- Thyroid function, autoimmunity, thyroid volume, and metabolic profile in people with Hashimoto thyroiditis.BMC endocrine disorders · 2024Article
- Association between total body muscle-fat ratio and risk of thyroid disorders: a cross-sectional study.BMC public health · 2024Article
- Could Vaspin Be a Potential Diagnostic Marker in Endometrial Cancer?International journal of environmental research and public health · 2023Article
- Thyroid stimulating hormone correlates with triglyceride levels but is not associated with the severity of acute ischemic stroke in patients with euthyroidism: a cross-sectional study.Annals of translational medicine · 2023Article
- Assessment of the relationship between subclinical hypothyroidism and blood lipid profile: reliable or not?Lipids in health and disease · 2022Article
- Update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism.Endocrine connections · 2022Review
- Serum lipids are novel predictors for thyroid autoimmunity in the general population with normal TSH levels from a cross-sectional study.Endocrine · 2021Article
- Relationship between Hypothyroidism and Endometrial Cancer.Aging and disease · 2019Review
- Benefits of Levothyroxine Replacement Therapy on Nonalcoholic Fatty Liver Disease in Subclinical Hypothyroidism Patients.International journal of endocrinology · 2017Article
- Gender impact on the correlation between thyroid function and serum lipids in patients with differentiated thyroid cancer.Experimental and therapeutic medicine · 2016Article
- Central hypothyroidism and its role for cardiovascular risk factors in hypopituitary patients.Endocrine · 2016Review
- Analysis of the correlation between lipotoxicity and pituitary-thyroid axis hormone levels in men and male rats.Oncotarget · 2016Article
- Gender and Age Impacts on the Association Between Thyroid Function and Metabolic Syndrome in Chinese.Medicine · 2015Observational
- Gender and Age Impact on the Association Between Thyroid-Stimulating Hormone and Serum Lipids.Medicine · 2015Observational
- Effects of levothyroxine replacement therapy on parameters of metabolic syndrome and atherosclerosis in hypothyroid patients: a prospective pilot study.International journal of endocrinology · 2015Article
- Thyroid Function, Prevalent Coronary Heart Disease, and Severity of Coronary Atherosclerosis in Patients Undergoing Coronary Angiography.International journal of endocrinology · 2015Article
- Endothelial Functioning and Hemodynamic Parameters in Rats with Subclinical Hypothyroid and the Effects of Thyroxine Replacement.PloS one · 2015Article
- Functional thyrotropin receptor expression in the ventricle and the effects on ventricular BNP secretion.Endocrine · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship between TSH and the lipid profile is contradictory because few studies have excluded the potential influence of the thyroid hormones (TH). The aim of the present study was to evaluate the relationship between serum TSH levels and the lipid profile independent of TH.
methods1302 CHD patients diagnosed by coronary angiography were retrospectively studied. The prevalence and distribution of thyroid dysfunction were analyzed first. To assess the impact of TSH on serum lipids, Pearson's correlation analysis was performed after adjustments for classic factors and TH. To calculate the extent of the effect of TSH on the serum cholesterol level, the partial least squares method and additional statistical methods were used.
resultsAfter the exclusions, a total of 568 patients (270 males and 298 females with a mean age of 63.56 ± 11.376 years) were selected. The prevalence of thyroid dysfunction among the patients was 18.66%, and the prevalence of hypothyroidism (15.32%) was higher than that of hyperthyroidism (3.34%). Even after adjusting for confounding factors, such as sex, age, smoking status, fasting plasma glucose levels and TH, a significant positive impact of TSH on the serum total cholesterol (TC) level was revealed (r = 0.095, p = 0.036). Each 1 mIU/L increase in the TSH level might be linked to a 0.015580712 mmol/L elevation of the serum TC value.
conclusionsTSH can increase the TC level in CHD patients independent of TH. The present study suggests a potential physiological role of TSH and the importance of maintaining an appropriate TSH level in CHD patients.
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Registered trials
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