Evidence map›Paper›PMID 22621191›Full record

ArticleExperimental dermatology2012

Myo/Nog cells in normal, wounded and tumor-bearing skin.

Jacquelyn Gerhart, Candace Hayes, Victoria Scheinfeld, Michael Chernick, Susan Gilmour, Mindy George-Weinstein

Erratum issuedOpen access · bronzeAbstract readLetter
In one paragraph

Article in Experimental dermatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. The expression patterns of gremlin 1 and noggin in normal adult and tumor tissues.International journal of clinical and experimental pathology · 2013
    Article
  12. Acquired Resilience: An Evolved System of Tissue Protection in Mammals.Dose-response : a publication of International Hormesis Society
    Review
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jacquelyn Gerhart
Candace Hayes
Victoria Scheinfeld
Michael Chernick
Susan Gilmour
Mindy George-Weinstein
Lankenau Institute for Medical Research · US

Funding

POLYAMINES AND EPITHELIAL TUMORIGENESISR01CA070739 · NCI · LANKENAU INSTITUTE FOR MEDICAL RESEARCH · PI GILMOUR, SUSAN K. · 1996 to 2010
$2.8M
Directing the Fate of Cells to Myogenic LineagesR01AR052326 · NIAMS · PHILADELPHIA COLLEGE OF OSTEOPATHIC MED · PI GEORGE-WEINSTEIN, MINDY · 2006 to 2010
$1.4M
NCI NIH HHS CA070739NCI NIH HHS R01 CA070739NIAMS NIH HHS AR052326NIAMS NIH HHS R01 AR052326
6 · The paper itself

Abstract

Murine and human skin were examined for the presence of Myo/Nog cells that were originally discovered in the chick embryo by their expression of MyoD mRNA, noggin and the G8 antigen. Myo/Nog cells are the primary source of noggin in telogen hair follicles. They are scarce within the interfollicular dermis and absent in the epidermis. Within 24 h following epidermal abrasion, Myo/Nog cells increase in number in the follicles and appear in the wound. Myo/Nog cells are also recruited to the stroma of tumors formed from v-Ras-transformed keratinocytes (Ker/Ras). Human squamous cell carcinomas and malignant melanomas contain significantly more Myo/Nog cells than basal cell carcinomas. Myo/Nog cells are distinct from macrophages, granulocytes and cells expressing alpha smooth muscle actin in the tumor stroma. Myo/Nog cells may be modulators of skin homoeostasis and wound healing, and potential diagnostic and therapeutic targets in skin cancer.

Indexed as

AnimalsBasal Cell CarcinomaCarcinoma, Squamous CellCarrier ProteinsHumansMelanomaMiceMyoD ProteinNoggin ProteinSkinSkin NeoplasmsWounds and InjuriesCarrier ProteinsMyoD ProteinNoggin Protein

Identifiers

PMID22621191
PMCPMC3367384
OpenAlexW2029075473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.