SynthesisJournal of natural products2012
Analysis and purification of bioactive natural products: the AnaPurNa study.
Synthesis in Journal of natural products, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Curcumin triggers reactive oxygen species-mediated apoptosis and suppresses tumor growth in metastatic oral squamous cell carcinoma.Frontiers in oncology · 2025Article
- Exploring the Nonenzymatic Origin of Duclauxin-like Natural Products.Journal of natural products · 2024Article
- Curcumin-Based Fixed Dose Combination Products for Cholesterol Management: A Narrative Review.ACS pharmacology & translational science · 2024Review
- Returning to Nature for the Next Generation of Antimicrobial Therapeutics.Antibiotics (Basel, Switzerland) · 2023Review
- The 4-α-Glucanotransferase AcbQ Is Involved in Acarbose Modification inMicroorganisms · 2023Article
- Overview on Strategies and Assays for Antibiotic Discovery.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Asymmetric Syntheses of (+)- and (-)-Collybolide Enable Reevaluation ofACS central science · 2022Article
- Investigation of red clover (Trifolium pratense) isoflavonoid residual complexity by off-line CCS-qHNMR.Fitoterapia · 2022Article
- Silica Gel-mediated Oxidation of Prenyl Motifs Generates Natural Product-Like Artifacts.Planta medica · 2021Article
- Auto-hydrolysis of red clover as "green" approach to (iso)flavonoid enriched products.Fitoterapia · 2021Article
- The Untargeted Capability of NMR Helps Recognizing Nefarious Adulteration in Natural Products.Journal of natural products · 2021Article
- The Essential Medicinal Chemistry of Cannabidiol (CBD).Journal of medicinal chemistry · 2020Review
- The marine-derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα.Journal of cellular and molecular medicine · 2020Article
- Systematic Isolation and Structure Elucidation of Urinary Metabolites Optimized for the Analytical-Scale Molecular Profiling Laboratory.Analytical chemistry · 2019Article
- Isolation, Structure, and Total Synthesis of the Marine Macrolide Mangrolide D.Organic letters · 2019Article
- Selective Depletion and Enrichment of Constituents in "Curcumin" and Other Curcuma longa Preparations.Journal of natural products · 2019Article
- Compatible and Incompatible Pollen-Styles Interaction inFrontiers in plant science · 2019Article
- Pharmacognosy in the digital era: shifting to contextualized metabolomics.Current opinion in biotechnology · 2018Review
- The Essential Medicinal Chemistry of Curcumin.Journal of medicinal chemistry · 2017Review
- Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?Journal of medicinal chemistry · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Based on a meta-analysis of data mined from almost 2000 publications on bioactive natural products (NPs) from >80000 pages of 13 different journals published in 1998-1999, 2004-2005, and 2009-2010, the aim of this systematic review is to provide both a survey of the status quo and a perspective for analytical methodology used for isolation and purity assessment of bioactive NPs. The study provides numerical measures of the common means of sourcing NPs, the chromatographic methodology employed for NP purification, and the role of spectroscopy and purity assessment in NP characterization. A link is proposed between the observed use of various analytical methodologies, the challenges posed by the complexity of metabolomes, and the inescapable residual complexity of purified NPs and their biological assessment. The data provide inspiration for the development of innovative methods for NP analysis as a means of advancing the role of naturally occurring compounds as a viable source of biologically active agents with relevance for human health and global benefit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.