ArticleNeural plasticity2012
Time to be SHY? Some comments on sleep and synaptic homeostasis.
Article in Neural plasticity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02732288 (Exploratory Study of Melatonin Induced Sleep Regularization in Severe Brain Injury), which is not on this map. Cited by 58 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exploratory Study of Melatonin Induced Sleep Regularization in Severe Brain Injury
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sleep deprivation and memory: Meta-analytic reviews of studies on sleep deprivation before and after learning.Psychological bulletin · 2021Pooled it
- Antidepressant effect of vagal nerve stimulation in epilepsy patients: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Pooled it
- High Resolution Topography of Age-Related Changes in Non-Rapid Eye Movement Sleep Electroencephalography.PloS one · 2016Trial
- Polygenic risk for schizophrenia is associated with psychomotor vigilance performance impairment during sleep deprivation in women.Translational psychiatry · 2026Article
- An integrative analysis of cell-specific transcriptomics and nuclear proteomics of sleep-deprived mouse cerebral cortex.Scientific reports · 2025Article
- Local versus global sleep organization and the quest to determine sleep function.Neurobiology of sleep and circadian rhythms · 2025Article
- Unraveling the Mysteries of Sleep: Exploring Phylogenomic Sleep Signals in the Recently Characterized Archaeal Phylum Lokiarchaeota near Loki's Castle.International journal of molecular sciences · 2024Article
- The causal relationship between sleep and risk of psychiatric disorders: A two-sample mendelian randomization study.Frontiers in genetics · 2024Article
- Brain oscillations in reflecting motor status and recovery induced by action observation-driven robotic hand intervention in chronic stroke.Frontiers in neuroscience · 2023Article
- The why and how of sleep-dependent synaptic down-selection.Seminars in cell & developmental biology · 2022Article
- A feedback control principle common to several biological and engineered systems.Journal of the Royal Society, Interface · 2022Review
- Brain-derived neurotrophic factor Val66Met polymorphism modulates the effects of circadian desynchronization on activity and sleep in male mice.Frontiers in neuroscience · 2022Article
- A Correspondence Between Normalization Strategies in Artificial and Biological Neural Networks.Neural computation · 2021Article
- Sleep-related hypermotor epilepsy and non-rapid eye movement parasomnias: Differences in the periodic and aperiodic component of the electroencephalographic power spectra.Journal of sleep research · 2021Article
- The Sleep Side of Aging and Alzheimer's Disease.Sleep medicine · 2021Review
- Prolonged Exposure to Social Stress Impairs Homeostatic Sleep Regulation.Frontiers in neuroscience · 2021Article
- Hemispheric Asymmetries in Electroencephalogram Oscillations for Long-Term Memory Retrieval in Healthy Individuals.Brain sciences · 2020Article
- Differential Gene Expression in Brain and Liver Tissue of Wistar Rats after Rapid Eye Movement Sleep Deprivation.Clocks & sleep · 2020Article
- Effects of sleep and waking on the synaptic ultrastructure.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Abnormal Sleep Signals Vulnerability to Chronic Social Defeat Stress.Frontiers in neuroscience · 2020Article
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Abstract
Sleep must serve an essential, universal function, one that offsets the risk of being disconnected from the environment. The synaptic homeostasis hypothesis (SHY) is an attempt to identify this essential function. Its core claim is that sleep is needed to reestablish synaptic homeostasis, which is challenged by the remarkable plasticity of the brain. In other words, sleep is "the price we pay for plasticity." In this issue, M. G. Frank reviewed several aspects of the hypothesis and raised several issues. The comments below provide a brief summary of the motivations underlying SHY and clarify that SHY is a hypothesis not about specific mechanisms, but about a universal, essential function of sleep. This function is the preservation of synaptic homeostasis in the face of a systematic bias toward a net increase in synaptic strength--a challenge that is posed by learning during adult wake, and by massive synaptogenesis during development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.