Evidence map›Paper›PMID 22619547›Full record

ArticleInternational journal of nanomedicine2012

Zerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm.

Rene Hernandez-Delgadillo, Donaji Velasco-Arias, David Diaz, Katiushka Arevalo-Niño, Marianela Garza-Enriquez, Myriam A De la Garza-Ramos, Claudio Cabral-Romero

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Nanomedicine: New Frontiers in Fighting Microbial Infections.Nanomaterials (Basel, Switzerland) · 2023
    Review
  6. Review
  7. Review
  8. Microflow synthesis and enhanced photocatalytic dye degradation performance of antibacterial BiEnvironmental science and pollution research international · 2021
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Potential applications of engineered nanoparticles in medicine and biology: an update.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2018
    Review
  17. Inhibitory Effect of Bismuth Oxide Nanoparticles Produced byIranian journal of biotechnology · 2018
    Article
  18. Review
  19. Nanomaterials for alternative antibacterial therapy.International journal of nanomedicine · 2017
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rene Hernandez-DelgadilloInstituto de Biotecnologia, Centro de Investigacion y Desarrollo en Ciencias de la Salud, CIDICS, Facultad de Odontologia, Universidad Autonoma de Nuevo Leon, UANL, Monterrey, Nuevo Leon, Mexico.
Donaji Velasco-Arias
David Diaz
Katiushka Arevalo-Niño
Marianela Garza-Enriquez
Myriam A De la Garza-Ramos
Claudio Cabral-Romero

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

methodsDespite continuous efforts, the increasing prevalence of resistance among pathogenic bacteria to common antibiotics has become one of the most significant concerns in modern medicine. Nanostructured materials are used in many fields, including biological sciences and medicine. While some bismuth derivatives has been used in medicine to treat vomiting, nausea, diarrhea, and stomach pain, the biocidal activity of zerovalent bismuth nanoparticles has not yet been studied. The objective of this investigation was to analyze the antimicrobial activity of bismuth nanoparticles against oral bacteria and their antibiofilm capabilities.

resultsOur results showed that stable colloidal bismuth nanoparticles had 69% antimicrobial activity against Streptococcus mutans growth and achieved complete inhibition of biofilm formation. These results are similar to those obtained with chlorhexidine, the most commonly used oral antiseptic agent. The minimal inhibitory concentration of bismuth nanoparticles that interfered with S. mutans growth was 0.5 mM.

conclusionThese results suggest that zerovalent bismuth nanoparticles could be an interesting antimicrobial agent to be incorporated into an oral antiseptic preparation.

Indexed as

Anti-Infective AgentsBiofilmsBismuthDrug Resistance, BacterialHumansIn Vitro TechniquesMetal NanoparticlesMicrobial Sensitivity TestsMicroscopy, Electron, TransmissionNanomedicineStreptococcus mutansAnti-Infective AgentsBismuthantimicrobial agentbiofilmStreptococcus mutanszerovalent bismuth nanoparticles

Identifiers

PMID22619547
PMCPMC3356212

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.