Evidence map›Paper›PMID 22619510›Full record

ReviewInternational journal of nanomedicine2012

Exosome mimetics: a novel class of drug delivery systems.

Sander A A Kooijmans, Pieter Vader, Susan M van Dommelen, Wouter W van Solinge, Raymond M Schiffelers

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of nanomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05624203 (Clinical Efficacy of Extracorporeal Cardiac Shock Wave Therapy in Patients With Ischemia-reperfusion Injury), which is not on this map. Cited by 259 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
259citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05624203 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Clinical Efficacy of Extracorporeal Cardiac Shock Wave Therapy in Patients With Ischemia-reperfusion Injury

TypeinterventionalSponsorFirst Affiliated Hospital of Kunming Medical UniversityRan2022 to 2024Enrolled100ConditionsMyocardial Reperfusion Injury, Treatment Outcome, Prognosis, ST Elevation Myocardial InfarctionArmsExtracorporeal cardiac shock wave therapy(ECSW)
3 · Its place in the literature

Who cites it

259 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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199 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sander A A KooijmansDepartment of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands.
Pieter Vader
Susan M van Dommelen
Wouter W van Solinge
Raymond M Schiffelers

Funding

European Research Council 260627
6 · The paper itself

Abstract

The identification of extracellular phospholipid vesicles as conveyors of cellular information has created excitement in the field of drug delivery. Biological therapeutics, including short interfering RNA and recombinant proteins, are prone to degradation, have limited ability to cross biological membranes, and may elicit immune responses. Therefore, delivery systems for such drugs are under intensive investigation. Exploiting extracellular vesicles as carriers for biological therapeutics is a promising strategy to overcome these issues and to achieve efficient delivery to the cytosol of target cells. Exosomes are a well studied class of extracellular vesicles known to carry proteins and nucleic acids, making them especially suitable for such strategies. However, the considerable complexity and the related high chance of off-target effects of these carriers are major barriers for translation to the clinic. Given that it is well possible that not all components of exosomes are required for their proper functioning, an alternative strategy would be to mimic these vesicles synthetically. By assembly of liposomes harboring only crucial components of natural exosomes, functional exosome mimetics may be created. The low complexity and use of well characterized components strongly increase the pharmaceutical acceptability of such systems. However, exosomal components that would be required for the assembly of functional exosome mimetics remain to be identified. This review provides insights into the composition and functional properties of exosomes, and focuses on components which could be used to enhance the drug delivery properties of exosome mimetics.

Indexed as

Biomimetic MaterialsDrug Delivery SystemsExosomesAnimalsBiotechnologyCell Adhesion MoleculesDrug CarriersHumansLiposomesMembrane LipidsMembrane ProteinsNanomedicineNanotechnologyRNA, Small InterferingTetraspaninsCell Adhesion MoleculesDrug CarriersLiposomesMembrane LipidsMembrane ProteinsRNA, Small InterferingTetraspaninsdrug delivery systemsexosomesextracellular vesiclesliposomes

Identifiers

PMID22619510
PMCPMC3356169

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.