ArticleMediators of inflammation2012
Lipid bodies: inflammatory organelles implicated in host-Trypanosoma cruzi interplay during innate immune responses.
Article in Mediators of inflammation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Metabolic reprogramming and lipid droplets are involved in Zika virus replication in neural cells.Journal of neuroinflammation · 2023Article
- A Data-Driven Approach to Construct a Molecular Map ofVaccines · 2023Article
- Lipid droplets as multifunctional organelles related to the mechanism of evasion during mycobacterial infection.Frontiers in cellular and infection microbiology · 2023Review
- Biogenesis and Breakdown of Lipid Droplets in Pathological Conditions.Frontiers in cell and developmental biology · 2021Review
- Pathology and Pathogenesis of Chagas Heart Disease.Annual review of pathology · 2019Review
- Increased BMPR1A Expression Enhances the Adipogenic Differentiation of Mesenchymal Stem Cells in Patients with Ankylosing Spondylitis.Stem cells international · 2019Article
- Lopinavir, an HIV-1 peptidase inhibitor, induces alteration on the lipid metabolism of Leishmania amazonensis promastigotes.Parasitology · 2018Article
- Lipid Bodies as Sites of Prostaglandin E2 Synthesis During Chagas Disease: Impact in the Parasite Escape Mechanism.Frontiers in microbiology · 2018Review
- Host triacylglycerols shape the lipidome of intracellular trypanosomes and modulate their growth.PLoS pathogens · 2017Article
- Distinct surveillance pathway for immunopathology during acute infection via autophagy and SR-BI.Scientific reports · 2016Article
- Lipid droplets in leukocytes: Organelles linked to inflammatory responses.Experimental cell research · 2016Review
- Lipid Body Organelles within the Parasite Trypanosoma cruzi: A Role for Intracellular Arachidonic Acid Metabolism.PloS one · 2016Article
- Article
- Trypanosoma cruzi infection and host lipid metabolism.Mediators of inflammation · 2014Review
- Lipid Droplets as Signaling Platforms Linking Metabolic and Cellular Functions.Lipid insights · 2014Article
- The internal architecture of leukocyte lipid body organelles captured by three-dimensional electron microscopy tomography.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The flagellated protozoa Trypanosoma cruzi is the causal agent of Chagas' disease, a significant public health issue and still a major cause of morbidity and mortality in Latin America. Acute Chagas' disease elicits a strong inflammatory response. In order to control the parasite multiplication, cells of the monocytic lineage are highly mobilized. Monocyte differentiation leads to the formation of phagocytosing macrophages, which are strongly activated and direct host defense. A distinguishing feature of Chagas' disease-triggered macrophages is the presence of increased numbers of distinct cytoplasmic organelles termed lipid bodies or lipid droplets. These organelles are actively formed in response to the parasite and are sites for synthesis and storage of inflammatory mediators. This review covers current knowledge on lipid bodies elicited by the acute Chagas' disease within inflammatory macrophages and discusses the role of these organelles in inflammation. The increased knowledge of lipid bodies in pathogenic mechanisms of infections may not only contribute to the understanding of pathogen-host interactions but may also identify new targets for intervention.
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