ArticleMediators of inflammation2012
oxLDL downregulates the dendritic cell homing factors CCR7 and CCL21.
Article in Mediators of inflammation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Inflammatory Chemokines in Atherosclerosis.Cells · 2021Review
- Construction of the circRNA-miRNA-mRNA Regulatory Network of an Abdominal Aortic Aneurysm to Explore Its Potential Pathogenesis.Disease markers · 2021Article
- CCL21/CCR7 signaling in macrophages promotes joint inflammation and Th17-mediated osteoclast formation in rheumatoid arthritis.Cellular and molecular life sciences : CMLS · 2020Article
- Screening key genes for abdominal aortic aneurysm based on gene expression omnibus dataset.BMC cardiovascular disorders · 2018Article
- Dendritic cell migration in health and disease.Nature reviews. Immunology · 2017Review
- Cigarette smoke affects dendritic cell maturation in the small airways of patients with chronic obstructive pulmonary disease.Molecular medicine reports · 2015Article
- Dendritic cells in atherosclerotic inflammation: the complexity of functions and the peculiarities of pathophysiological effects.Frontiers in physiology · 2014Review
- The role of the vascular dendritic cell network in atherosclerosis.American journal of physiology. Cell physiology · 2013Review
- Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.Cardiovascular research · 2013Article
- LOX-1, OxLDL, and atherosclerosis.Mediators of inflammation · 2013Review
- Macrophages, dendritic cells, and regression of atherosclerosis.Frontiers in physiology · 2012Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDendritic cells (DCs) and oxLDL play an important role in the atherosclerotic process with DCs accumulating in the plaques during plaque progression. Our aim was to investigate the role of oxLDL in the modulation of the DC homing-receptor CCR7 and endothelial-ligand CCL21. METHODS AND
resultsThe expression of the DC homing-receptor CCR7 and its endothelial-ligand CCL21 was examined on atherosclerotic carotic plaques of 47 patients via qRT-PCR and immunofluorescence. In vitro, we studied the expression of CCR7 on DCs and CCL21 on human microvascular endothelial cells (HMECs) in response to oxLDL. CCL21- and CCR7-mRNA levels were significantly downregulated in atherosclerotic plaques versus non-atherosclerotic controls [90% for CCL21 and 81% for CCR7 (P < 0.01)]. In vitro, oxLDL reduced CCR7 mRNA levels on DCs by 30% and protein levels by 46%. Furthermore, mRNA expression of CCL21 was significantly reduced by 50% (P < 0.05) and protein expression by 24% in HMECs by oxLDL (P < 0.05).
conclusionsThe accumulation of DCs in atherosclerotic plaques appears to be related to a downregulation of chemokines and their ligands, which are known to regulate DC migration. oxLDL induces an in vitro downregulation of CCR7 and CCL21, which may play a role in the reduction of DC migration from the plaques.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.