ArticleBMJ open2012
Do statins improve outcomes in patients with asthma on inhaled corticosteroid therapy? A retrospective cohort analysis.
Article in BMJ open, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Absolute eosinophils count and the extent of coronary artery disease: a single centre cohort study.Journal of thrombosis and thrombolysis · 2015Trial
- Sterols and immune mechanisms in asthma.The Journal of allergy and clinical immunology · 2023Review
- Simvastatin Reduces NETosis to Attenuate Severe Asthma by Inhibiting PAD4 Expression.Oxidative medicine and cellular longevity · 2023Article
- Sterols in asthma.Trends in immunology · 2022Review
- Repositioned Drugs for Inflammatory Diseases such as Sepsis, Asthma, and Atopic Dermatitis.Biomolecules & therapeutics · 2020Review
- Statin for Tuberculosis and Pneumonia in Patients with Asthma⁻Chronic Pulmonary Disease Overlap Syndrome: A Time-Dependent Population-Based Cohort Study.Journal of clinical medicine · 2018Article
- Anti-asthmatic effect of pitavastatin through aerosol inhalation is associated with CD4+ CD25+ Foxp3+ T cells in an asthma mouse model.Scientific reports · 2017Article
- Fluvastatin Suppresses Mast Cell and Basophil IgE Responses: Genotype-Dependent Effects.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Regulation of Adaptive Immunity in Health and Disease by Cholesterol Metabolism.Current allergy and asthma reports · 2015Review
- Impact of Statins on Gene Expression in Human Lung Tissues.PloS one · 2015Article
- Attenuation of airway inflammation by simvastatin and the implications for asthma treatment: is the jury still out?Experimental & molecular medicine · 2014Article
- Novel simvastatin inhalation formulation and characterisation.AAPS PharmSciTech · 2014Article
- Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.Pharmacology & therapeutics · 2014Review
- Statins and asthma: where we stand, and the next critical steps in research.Current medical research and opinion · 2014Article
- Statin use in asthmatics on inhaled corticosteroids is associated with decreased risk of emergency department visits.Current medical research and opinion · 2014Article
- Statin exposure is associated with decreased asthma-related emergency department visits and oral corticosteroid use.American journal of respiratory and critical care medicine · 2013 · on this mapObservational
- Article
- Statins as potential therapeutic drug for asthma?Respiratory research · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAnimal studies and clinical trials have examined the potential benefits of statins in asthma management with contradictory results. The objective of this study was to determine if asthma patients on concurrent statins are less likely to have asthma-related hospitalisations.
designA retrospective cohort study using Mississippi Medicaid data for 2002-2004.
participantsAsthma patients ≥18 years were identified using the ICD9 code 493.xx from 1 July 2002 through 31 December 2003. The index date for an exposed subject was any date within the identification period, 180 days prior to which the subject had at least one inhaled corticosteroid prescription and at least an 80% adherence rate to statins. Asthma patients on inhaled corticosteroids, but not on statins, were selected as the unexposed population. The two groups were matched and followed for 1 year beginning the index date. MAIN OUTCOMES MEASURES: Patient outcomes in terms of hospitalisations and ER visits were compared using conditional logistic regression.
resultsAfter matching, there were 479 exposed subjects and 958 corresponding unexposed subjects. The odds of asthma-related hospitalisation and/or emergency room (ER) visits for asthma patients on concurrent statins were almost half the odds for patients not on statins (OR=0.55; 95% CI (0.37 to 0.84); p=0.0059). Similarly, the odds of asthma-related ER visits were significantly lower for patients on statins (OR=0.48; 95% CI (0.28 to 0.82); p=0.0069).
conclusionThe findings suggest beneficial effects of statins in asthma management. Further prospective investigations are required to provide more conclusive evidence.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.