ArticleNMR in biomedicine2012
Oxygenation in cervical cancer and normal uterine cervix assessed using blood oxygenation level-dependent (BOLD) MRI at 3T.
Article in NMR in biomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Understanding Immune Cell Adaptation to Tumor Hypoxia for Maximized Therapeutic Efficacy of Immunotherapy: Biology and Non-invasive Imaging Application.Cancer research and treatment · 2026Review
- Temporal changes in native and late gadolinium enhanced ultrashort echo time magnetic resonance imaging during gynecologic cancer radiation therapy.Physics and imaging in radiation oncology · 2025Article
- Information theoretic evaluation of Lorentzian, Gaussian, Voigt, and symmetric alpha-stable models of reversible transverse relaxation in cervical cancer in vivo at 3 T.Magma (New York, N.Y.) · 2023Article
- The Challenges of OInternational journal of molecular sciences · 2022Review
- Targeting hypoxia in solid and haematological malignancies.Journal of experimental & clinical cancer research : CR · 2022Review
- Radiomic Analysis for Pretreatment Prediction of Recurrence Post-Radiotherapy in Cervical Squamous Cell Carcinoma Cancer.Diagnostics (Basel, Switzerland) · 2022Article
- T2*-weighted imaging and diffusion kurtosis imaging (DKI) of rectal cancer: correlation with clinical histopathologic prognostic factors.Abdominal radiology (New York) · 2022Article
- Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics.International journal of molecular sciences · 2022Review
- Hypoxia and the phenomenon of immune exclusion.Journal of translational medicine · 2021Review
- Quantitative T2*-Weighted Imaging and Reduced Field-of-View Diffusion-Weighted Imaging of Rectal Cancer: Correlation of R2* and Apparent Diffusion Coefficient With Histopathological Prognostic Factors.Frontiers in oncology · 2021Article
- The clinical utility of imaging methods used to measure hypoxia in cervical cancer.The British journal of radiology · 2020Review
- Value of blood oxygenation level-dependent MRI for predicting clinical outcomes in uterine cervical cancer treated with concurrent chemoradiotherapy.European radiology · 2019Article
- The effect of flow on blood oxygen level dependent (RMagnetic resonance in medicine · 2019Article
- Molecular and functional imaging insights into the role of hypoxia in cancer aggression.Cancer metastasis reviews · 2019Review
- Effect of radiochemotherapy on T2* MRI in HNSCC and its relation to FMISO PET derived hypoxia and FDG PET.Radiation oncology (London, England) · 2018Article
- Emerging Magnetic Resonance Imaging Technologies for Radiation Therapy Planning and Response Assessment.International journal of radiation oncology, biology, physics · 2018Review
- Pre-clinical imaging of transgenic mouse models of neuroblastoma using a dedicated 3-element solenoid coil on a clinical 3T platform.British journal of cancer · 2017Article
- Incorporating Oxygen-Enhanced MRI into Multi-Parametric Assessment of Human Prostate Cancer.Diagnostics (Basel, Switzerland) · 2017Article
- Tumor physiological changes during hypofractionated stereotactic body radiation therapy assessed using multi-parametric magnetic resonance imaging.Oncotarget · 2017Article
- External beam techniques to boost cervical cancer when brachytherapy is not an option-theories and applications.Annals of translational medicine · 2017Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Hypoxia is reported to be a biomarker for poor prognosis in cervical cancer. However, a practical noninvasive method is needed for the routine clinical evaluation of tumor hypoxia. This study examined the potential use of blood oxygenation level-dependent (BOLD) contrast MRI as a noninvasive technique to assess tumor vascular oxygenation at 3T. Following Institutional Review Board-approved informed consent and in compliance with the Health Insurance Portability and Accountability Act, successful results were achieved in nine patients with locally advanced cervical cancer [International Federation of Gynecology and Obstetrics (FIGO) stage IIA to IVA] and three normal volunteers. In the first four patients, dynamic T₂*-weighted MRI was performed in the transaxial plane using a multi-shot echo planar imaging sequence whilst patients breathed room air followed by oxygen (15 dm³/min). Later, a multi-echo gradient echo examination was added to provide quantitative R₂* measurements. The baseline T₂*-weighted signal intensity was quite stable, but increased to various extents in tumors on initiation of oxygen breathing. The signal in normal uterus increased significantly, whereas that in the iliacus muscle did not change. R₂* responded significantly in healthy uterus, cervix and eight cervical tumors. This preliminary study demonstrates that BOLD MRI of cervical cancer at 3T is feasible. However, more patients must be evaluated and followed clinically before any prognostic value can be determined.
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