ArticlePhytotherapy research : PTR2013
Tea tree oil-induced transcriptional alterations in Staphylococcus aureus.
Article in Phytotherapy research : PTR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Terpenes as bacterial efflux pump inhibitors: A systematic review.Frontiers in pharmacology · 2022Pooled it
- Unique structural and ligand-binding properties of theProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Unique structural and ligand binding properties of thebioRxiv : the preprint server for biology · 2025Article
- Tea Tree Oil: Properties and the Therapeutic Approach to Acne-A Review.Antioxidants (Basel, Switzerland) · 2023Review
- Transcriptomic analyses reveal the potential antibacterial mechanism of citral againstFrontiers in microbiology · 2023Article
- Essential Oils: A Natural Weapon against Antibiotic-Resistant Bacteria Responsible for Nosocomial Infections.Antibiotics (Basel, Switzerland) · 2021Article
- Natural Agents against Bovine Mastitis Pathogens.Antibiotics (Basel, Switzerland) · 2021Article
- Antimicrobial, Antibiofilm, and Anti-persister Activities of Penfluridol AgainstFrontiers in microbiology · 2021Article
- The protective roles of tea tree oil extracts in bovine mammary epithelial cells and polymorphonuclear leukocytes.Journal of animal science and biotechnology · 2020Article
- Proteomic and Metabolomic Analyses of a Tea-Tree Oil-SelectedAntibiotics (Basel, Switzerland) · 2019Article
- Identification of Staphylococcus aureus Cellular Pathways Affected by the Stilbenoid Lead Drug SK-03-92 Using a Microarray.Antibiotics (Basel, Switzerland) · 2017Article
- Adaptation to NaCl Reduces the Susceptibility of Enterococcus faecalis to Melaleuca alternifolia (Tea Tree) Oil.Current microbiology · 2015Article
- Article
- Quantitative proteomic view associated with resistance to clinically important antibiotics in Gram-positive bacteria: a systematic review.Frontiers in microbiology · 2015Review
- Mutations in mmpL and in the cell wall stress stimulon contribute to resistance to oxadiazole antibiotics in methicillin-resistant Staphylococcus aureus.Antimicrobial agents and chemotherapy · 2014Article
- The isolation of Staphylococcus aureus tea tree oil-reduced susceptibility mutants.Phytotherapy research : PTR · 2014Article
- Chemical Composition and Antibacterial Activity of Essential Oil of Cosmos bipinnatus Cav. Leaves from South Africa.Iranian journal of pharmaceutical research : IJPR · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Tea tree oil (TTO) is a steam distillate of Melaleuca alternifolia that demonstrates broad-spectrum antibacterial activity. This study was designed to document how TTO challenge influences the Staphylococcus aureus transcriptome. Overall, bioinformatic analyses (S. aureus microarray meta-database) revealed that both ethanol and TTO induce related transcriptional alterations. TTO challenge led to the down-regulation of genes involved with energy-intensive transcription and translation, and altered the regulation of genes involved with heat shock (e.g. clpC, clpL, ctsR, dnaK, groES, groEL, grpE and hrcA) and cell wall metabolism (e.g. cwrA, isaA, sle1, vraSR and vraX). Inactivation of the heat shock gene dnaK or vraSR which encodes a two-component regulatory system that responds to peptidoglycan biosynthesis inhibition led to an increase in TTO susceptibility which demonstrates a protective role for these genes in the S. aureus TTO response. A gene (mmpL) encoding a putative resistance, nodulation and cell division efflux pump was also highly induced by TTO. The principal antimicrobial TTO terpene, terpinen-4-ol, altered ten genes in a transcriptional direction analogous to TTO. Collectively, this study provides additional insight into the response of a bacterial pathogen to the antimicrobial terpene mixture TTO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.