Trial reportWorld journal of surgery2012
Effect of triclosan-coated sutures on the incidence of surgical wound infection after lower limb revascularization surgery: a randomized controlled trial.
Trial report in World journal of surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03395613 (Prophylactic Use of a Negative Pressure Incision Management System in Infrainguinal Vascular Surgery - A Multicentre Randomized Controlled Trial), which is not on this map. Cited by 11 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prophylactic Use of a Negative Pressure Incision Management System in Infrainguinal Vascular Surgery - A Multicentre Randomized Controlled Trial
Who cites it
11 citing papers in PubMed, 6 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Triclosan-Containing Sutures for the Prevention of Surgical Site Infection: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- Plus Sutures for preventing surgical site infection: a systematic review of clinical outcomes with economic and environmental models.BMC surgery · 2023Pooled it
- The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature.BMJ open · 2019Pooled it
- Antimicrobial-coated sutures to decrease surgical site infections: a systematic review and meta-analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Pooled it
- Meta-analysis of prevention of surgical site infections following incision closure with triclosan-coated sutures: robustness to new evidence.Surgical infections · 2014Pooled it
- Continuous versus interrupted skin sutures for non-obstetric surgery.The Cochrane database of systematic reviews · 2014Pooled it
- Prophylactic use of incisional negative pressure wound therapy for groin incisions in vascular surgery: randomized clinical trial.BJS open · 2025Trial
- Triclosan-coated sutures reduce surgical site infection after open vein harvesting in coronary artery bypass grafting patients: a randomized controlled trial.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2013Trial
- Effect of a new incision management system (PREVENA®) on wound healing after endophlebectomy of the common femoral vein: a case series.Journal of medical case reports · 2016Article
- Staphylococcus epidermidis isolated in 1965 are more susceptible to triclosan than current isolates.PloS one · 2013Article
- Effect of triclosan-coated sutures on incidence of surgical wound infection after lower limb revascularization surgery: a randomized controlled trial. By Turtiainen et al. DOI:10.1007/s00268-012-1655-4.World journal of surgery · 2012Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgical wound infection (SWI) is a common complication after peripheral vascular surgery. In a prospective study, triclosan-coated sutures were reported to decrease the incidence of surgical site infection after various surgical procedures. The aim of our study was to test the hypothesis that use of triclosan-coated sutures decreases the incidence of SWI after lower limb vascular surgery.
methodsThis prospective, randomized, multicenter, double-blinded trial was conducted between July 2010 and January 2011 in five hospitals in Finland. We randomly allocated 276 patients undergoing lower limb revascularization surgery to a study (n = 139) or a control (n = 137) group. Surgical wounds in the study group were closed with triclosan-coated suture material, and wounds in the control group were closed with noncoated sutures. The main outcome measure was SWI. A surgical wound complication was considered to be an infection if there were bacteria isolated from the wound or if there were areas of localized redness, heat, swelling, and pain around the wound appearing within 30 days after the operative procedure. Logistic regression analysis was used to assess the independent effect of triclosan-coated sutures on the incidence of SWI.
resultsAltogether, 61 (22.1 %) patients developed SWI. SWI occurred in 31 (22.3 %) patients in the study group and in 30 (21.9 %) patients in the control group (odds ratio 1.10, 95% confidence interval 0.61-2.01, p = 0.75.)
conclusionsThe use of triclosan-coated sutures does not reduce the incidence of SWI after lower limb vascular surgery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.