ArticleAnnals of surgical oncology2012
The New American Joint Committee on Cancer/International Union Against Cancer staging system for adenocarcinoma of the stomach: increased complexity without clear improvement in predictive accuracy.
Article in Annals of surgical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Evaluation of the seventh AJCC TNM staging system for gastric cancer: a meta-analysis of cohort studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Evaluation of three lymph node staging systems for prognostic prediction in gastric cancer: A systematic review and meta-analysis.World journal of gastrointestinal oncology · 2025Article
- Establishment of a 7-gene expression panel to improve the prognosis classification of gastric cancer patients.Frontiers in genetics · 2023Article
- Revisiting the 8th AJCC system for gastric cancer: A review on validations, nomograms, lymph nodes impact, and proposed modifications.Annals of medicine and surgery (2012) · 2022Review
- Design and Development of an Intelligent System for Predicting 5-Year Survival in Gastric Cancer.Clinical Medicine Insights. Oncology · 2022Article
- miR-125a-5p promotes gastric cancer growth and invasion by regulating the Hippo pathway.Journal of clinical laboratory analysis · 2021Article
- The New American Joint Committee on Cancer T staging system for stomach: increased complexity without clear improvement in predictive accuracy for endoscopic ultrasound.BMC gastroenterology · 2021Article
- The Discordance of Clinical and Pathologic Staging in Locally Advanced Gastric Adenocarcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- A nomogram based on pretreatment levels of serum bilirubin and total bile acid levels predicts survival in colorectal cancer patients.BMC cancer · 2021Article
- Development and External Validation of a Nomogram for Predicting Overall Survival in Stomach Cancer: A Population-Based Study.Journal of healthcare engineering · 2021Article
- Multicenter Validation Study of the American Joint Commission on Cancer (8th Edition) for Gastric Cancer: Proposal for a Simplified and Improved TNM Staging System.Journal of Cancer · 2020Article
- Adrenergic modulation of AMPK‑dependent autophagy by chronic stress enhances cell proliferation and survival in gastric cancer.International journal of oncology · 2019Article
- A Simplified Two-Step Technique for Extended Lymphadenectomy During Resection of Gastroesophageal Malignancy: Early Results Compared to En Bloc Dissection.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019Article
- Comparison of Outcomes for Elderly Gastric Cancer Patients at Least 80 Years of Age Following Gastrectomy in the United States and China.Annals of surgical oncology · 2018Article
- The 8th edition of the American Joint Committee on Cancer tumor-node-metastasis staging system for gastric cancer is superior to the 7th edition: results from a Chinese mono-institutional study of 1663 patients.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2018Article
- Metastatic lymph node ratio and Lauren classification are independent prognostic markers for survival rates of patients with gastric cancer.Oncology letters · 2018Article
- Article
- Targeted literature review of the global burden of gastric cancer.Ecancermedicalscience · 2018Review
- The prognosis role of AJCC/UICC 8American journal of translational research · 2018Article
- Comparison of different lymph node staging systems in prognosis of gastric cancer: a bi-institutional study from Hungary.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2017Article
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6 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo evaluate the changes in the 7th edition American Joint Committee on Cancer (AJCC) staging system for stomach cancer compared to the 6th edition; to compare the predictive accuracy of the two staging systems.
methodsIn a combined database containing 2,196 patients who underwent an R0 resection for gastric adenocarcinoma, differences between the two staging systems were evaluated and stage-specific survival estimates compared. Concordance probability and Brier scores were estimated for both systems to examine the predictive accuracy.
resultsNodal status cutoff values were changed, leading to a more even distribution for the redefined N1, N2, and N3 group. AJCC 6th edition stage II reflected a highly heterogeneous population, which is now adequately subdivided in the AJCC 7th edition into stages IIA, IIB, and IIIA. The predictive accuracy of N classification improved significantly as measured by concordance. Despite increased complexity, the predictive accuracy of AJCC 7th stage grouping was significantly worse than that of the AJCC 6th edition. DISCUSSION: The increased complexity of the 7th edition staging system is accompanied by improvements in the predictive value of nodal staging as compared to the 6th edition, but it was no better in overall stage-specific predictive accuracy. Future refinements of the tumor, node, metastasis staging system should consider whether increased complexity is balanced by improved prognostic accuracy.
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