ArticleMetabolic brain disease2012
Regional reduction in gray and white matter volume in brains of cirrhotic patients: voxel-based analysis of MRI.
Article in Metabolic brain disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Brain Gray Matter Alterations in Hepatic Encephalopathy: A Voxel-Based Meta-Analysis of Whole-Brain Studies.Frontiers in human neuroscience · 2022Pooled it
- Grey and white matter abnormalities in minimal hepatic encephalopathy: a study combining voxel-based morphometry and tract-based spatial statistics.European radiology · 2013Trial
- Does Reflective Thinking Improve the Ability to Plan in Light and Heavy Drinkers? A Clinical-Experimental Model of Metacognition.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Structural and functional neural correlates of sensorimotor deficits in progression of hepatic encephalopathy.Magnetic resonance letters · 2025Article
- Assessment of microstructural abnormalities in gray and white matter of minimal hepatic encephalopathy patients using diffusion kurtosis imaging and their associations with neurocognitive dysfunction.Frontiers in human neuroscience · 2025Article
- Association of liver disease with brain volume loss, cognitive decline, and plasma neurodegenerative disease biomarkers.Neurobiology of aging · 2022Article
- Spontaneous Bilateral Subdural Hematomas in a Patient With Cryptogenic Liver Cirrhosis.Cureus · 2021Article
- Brain Structural Changes in Patients with Pulmonary Arterial Hypertension.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021Article
- Radiomics-based classification models for HBV-related cirrhotic patients with covert hepatic encephalopathy.Brain and behavior · 2021Article
- Associations of Serum Liver Function Markers With Brain Structure, Function, and Perfusion in Healthy Young Adults.Frontiers in neurology · 2021Article
- Identification of patients with and without minimal hepatic encephalopathy based on gray matter volumetry using a support vector machine learning algorithm.Scientific reports · 2020Article
- Atypical neuroimaging findings in patients with acquired hepatocerebral degeneration.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Reduced Cortical Complexity in Cirrhotic Patients with Minimal Hepatic Encephalopathy.Neural plasticity · 2020Article
- Structural and functional abnormalities of vision-related brain regions in cirrhotic patients: a MRI study.Neuroradiology · 2019Article
- Multimodal MR imaging in hepatic encephalopathy: state of the art.Metabolic brain disease · 2018Review
- Altered Topological Properties of Gray Matter Structural Covariance Networks in Minimal Hepatic Encephalopathy.Frontiers in neuroanatomy · 2018Article
- The Aging Brain With HIV Infection: Effects of Alcoholism or Hepatitis C Comorbidity.Frontiers in aging neuroscience · 2018Review
- Diabetes Mellitus is Associated with More Severe Brain Spontaneous Activity Impairment and Gray Matter Loss in Patients with Cirrhosis.Scientific reports · 2017Article
- Recent Updates on Acquired Hepatocerebral Degeneration.Tremor and other hyperkinetic movements (New York, N.Y.) · 2017Review
- Reduced cortical thickness in patients with acute-on-chronic liver failure due to non-alcoholic etiology.Journal of translational medicine · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic hepatic encephalopathy is a characteristically reversible neuropsychiatric disorder that occurs mainly in patients with liver cirrhosis. The brain regions critically involved in the pathophysiology of cirrhosis are not clear. Magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) is a valuable tool for evaluating structural brain changes in many neurodegenerative diseases. We performed an MRI scan on 18 patients with liver cirrhosis and 16 age-matched healthy controls. We evaluated brain regional structural changes, regional differences and the relationship of these changes with the blood levels of ammonia and the results of neuropsychological tests in patients with cirrhosis. The VBM showed reduction in the volume of gray matter in the cerebellum and occipital lobe and in the volume of white matter in the cingulate, parietal, temporal, occipital lobe and precentral area in cirrhotic patients compared with controls. There were significant correlations between the volume of these regions with the plasma levels of ammonia and the results of neuropsychological tests. Voxel-based analysis of MRI revealed evidence for structural abnormalities of brain in patients with cirrhosis. Abnormal function in the above regions may account for the ammonia-mediated changes and neuropsychological deficits in hepatic encephalopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.