ArticleMolecular systems biology2012
Transcription start site associated RNAs in bacteria.
Article in Molecular systems biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 51 citations in OpenAlex.
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- ProTInSeq: transposon insertion tracking by ultra-deep DNA sequencing to identify translated large and small ORFs.Nature communications · 2024Article
- Comprehensive quantitative modeling of translation efficiency in a genome-reduced bacterium.Molecular systems biology · 2023Article
- Full-length transcriptome profiling ofHeliyon · 2023Article
- Genome Engineering of the Fast-GrowingACS synthetic biology · 2022Article
- Integrative characterization of the near-minimal bacterium Mesoplasma florum.Molecular systems biology · 2020Article
- Redefining fundamental concepts of transcription initiation in bacteria.Nature reviews. Genetics · 2020Review
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- Unraveling the hidden universe of small proteins in bacterial genomes.Molecular systems biology · 2019Article
- Global analysis of sRNA target genes in Mycoplasma hyopneumoniae.BMC genomics · 2018Article
- Classification of Transcription Boundary-Associated RNAs (TBARs) in Animals and Plants.Frontiers in genetics · 2018Review
- A reporter system coupled with high-throughput sequencing unveils key bacterial transcription and translation determinants.Nature communications · 2017Article
- Article
- Insights into the Mechanisms of Basal Coordination of Transcription Using a Genome-Reduced Bacterium.Cell systems · 2016Article
- Bacterial antisense RNAs are mainly the product of transcriptional noise.Science advances · 2016Article
- Integration of multi-omics data of a genome-reduced bacterium: Prevalence of post-transcriptional regulation and its correlation with protein abundances.Nucleic acids research · 2016Article
- Distinguishing between productive and abortive promoters using a random forest classifier in Mycoplasma pneumoniae.Nucleic acids research · 2015Article
- Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium.Molecular systems biology · 2015Article
- MyMpn: a database for the systems biology model organism Mycoplasma pneumoniae.Nucleic acids research · 2015Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here, we report the genome-wide identification of small RNAs associated with transcription start sites (TSSs), termed tssRNAs, in Mycoplasma pneumoniae. tssRNAs were also found to be present in a different bacterial phyla, Escherichia coli. Similar to the recently identified promoter-associated tiny RNAs (tiRNAs) in eukaryotes, tssRNAs are associated with active promoters. Evidence suggests that these tssRNAs are distinct from previously described abortive transcription RNAs. ssRNAs have an average size of 45 bases and map exactly to the beginning of cognate full-length transcripts and to cryptic TSSs. Expression of bacterial tssRNAs requires factors other than the standard RNA polymerase holoenzyme. We have found that the RNA polymerase is halted at tssRNA positions in vivo, which may indicate that a pausing mechanism exists to prevent transcription in the absence of genes. These results suggest that small RNAs associated with TSSs could be a universal feature of bacterial transcription.
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