ArticleMucosal immunology2012
Regulatory role of suppressive motifs from commensal DNA.
Article in Mucosal immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 70 citations in OpenAlex.
- Trial
- An In Silico Omics Investigation of the Lactobacillus Genus Complex for Allergenicity Mitigation.Immunity, inflammation and disease · 2026Article
- Striking a balance: how the gut microbiome shapes the fate of intestinal CD4+ T cells.Discovery immunology · 2026Review
- Lactobacilli-Derived Microbe-Associated Molecular Patterns (MAMPs) in Host Immune Modulation.Biomolecules · 2025Review
- Modulating Microbiota as a New Strategy for Breast Cancer Prevention and Treatment.Microorganisms · 2022Review
- Your Regulatory T Cells Are What You Eat: How Diet and Gut Microbiota Affect Regulatory T Cell Development.Frontiers in nutrition · 2022Review
- Probiotics, Prebiotics, and Synbiotics: Implications and Beneficial Effects against Irritable Bowel Syndrome.Nutrients · 2021Review
- Dietary Supplementation with FermentedNutrients · 2021Article
- Physical properties of lactic acid bacteria influence the level of protection against influenza infection in mice.PloS one · 2021Article
- Treg-inducing capacity of genomic DNA ofAllergy and asthma proceedings · 2020Article
- Article
- The Control of Intestinal Inflammation: A Major Objective in the Research of Probiotic Strains as Alternatives to Antibiotic Growth Promoters in Poultry.Microorganisms · 2020Review
- Microbiome and Breast Cancer: New Role for an Ancient Population.Frontiers in oncology · 2020Review
- Role of the Intestinal Epithelium and Its Interaction With the Microbiota in Food Allergy.Frontiers in immunology · 2020Review
- Human Milk's Hidden Gift: Implications of the Milk Microbiome for Preterm Infants' Health.Nutrients · 2019Review
- Synthetic Biology and the Gut Microbiome.Biotechnology journal · 2018Review
- Composition and immuno-stimulatory properties of extracellular DNA from mouse gut flora.World journal of gastroenterology · 2017Article
- Review
- TLR4 and TLR21 expression, MIF, IFN-β, MD-2, CD14 activation, and sIgA production in chickens administered with EFAL41 strain challenged with Campylobacter jejuni.Folia microbiologica · 2017Article
- Role of intestinal microbiota and metabolites on gut homeostasis and human diseases.BMC immunology · 2017Review
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
The microbiota contributes to the induction of both effector and regulatory responses in the gastrointestinal (GI) tract. However, the mechanisms controlling these distinct properties remain poorly understood. We previously showed that commensal DNA promotes intestinal immunity. Here, we find that the capacity of bacterial DNA to stimulate immune responses is species specific and correlated with the frequency of motifs known to exert immunosuppressive function. In particular, we show that the DNA of Lactobacillus species, including various probiotics, is enriched in suppressive motifs able to inhibit lamina propria dendritic cell activation. In addition, immunosuppressive oligonucleotides sustain T(reg) cell conversion during inflammation and limit pathogen-induced immunopathology and colitis. Altogether, our findings identify DNA-suppressive motifs as a molecular ligand expressed by commensals and support the idea that a balance between stimulatory and regulatory DNA motifs contributes to the induction of controlled immune responses in the GI tract and gut immune homeostasis. Further, our findings suggest that the endogenous regulatory capacity of DNA motifs enriched in some commensal bacteria could be exploited for therapeutic purposes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.