ReviewCurrent opinion in rheumatology2012
Role of Helicobacter pylori infection in autoimmune diseases.
Review in Current opinion in rheumatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Helicobacter pylori infection and risk of multiple sclerosis: an updated meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Epidemiology of Helicobacter pylori infection among the healthy population in Iran and countries of the Eastern Mediterranean Region: a systematic review of prevalence and risk factors.World journal of gastroenterology · 2014Pooled it
- Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding loci†.Human molecular genetics · 2015Trial
- Clinical Pathologic Profiles ofJournal of clinical medicine · 2025Article
- Atrophic Gastritis and Autoimmunity: Results from a Prospective, Multicenter Study.Diagnostics (Basel, Switzerland) · 2023Article
- Anti-diabetics and antimicrobials: Harmony of mutual interplay.World journal of diabetes · 2021Review
- Article
- Increased Risk of Systemic Lupus Erythematosus in Patients WithFrontiers in medicine · 2019Article
- Associations between Antibiotics for Non-tuberculous Mycobacterial Infection and Incident Sjögren's Syndrome: A Nationwide, Population-based Case-control Study.Scientific reports · 2018Article
- Early life socioeconomic position and immune response to persistent infections among elderly Latinos.Social science & medicine (1982) · 2016Article
- Potential protective effect of Helicobacter pylori on the development of gastrointestinal GvHD.Bone marrow transplantation · 2016Article
- Gastric lesions in patients with Crohn's disease in Korea: a multicenter study.Intestinal research · 2016Article
- Unmet needs in autoimmunity and potential new tools.Clinical reviews in allergy & immunology · 2014Review
- Helicobacter pylori infection: new pathogenetic and clinical aspects.World journal of gastroenterology · 2014Review
- An association between Helicobacter pylori and upper respiratory tract disease: fact or fiction?World journal of gastroenterology · 2014Review
- Helicobacter pylori and Systemic Disease.Gastroenterology research and practice · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThe etiology of most autoimmune diseases remains elusive. Prevailing evidence suggests an environmental trigger in a genetically susceptible individual. Helicobacter pylori (H. pylori) have managed to survive in a hostile environment in their host for long period and have evaded eradication by the immune system. Its chronic interaction with the immune system and the ubiquitous presence worldwide makes H. pylori an ideal candidate to study as a trigger of autoimmune phenomena. In this review, we would present data regarding the interplay between H. pylori and various components of the immune system and its association with various autoimmune diseases. RECENT
findingsStrong associations of H. pylori with some autoimmune diseases such as immune thrombocytopenia have been found; but most other autoimmune disease studies have revealed conflicting data. The chronic survival of H. pylori in humans is possible because of an overall downregulation of the body's immune response. In addition to this overall effect on the immune system, there are clinical and epidemiological data suggestive of H. pylori infection having a protective role in some autoimmune diseases. SUMMARY: Based on our review H. pylori status should be checked and treated only in certain autoimmune diseases such as ITP. For the majority of the autoimmune diseases, the role of H. pylori remains controversial signifying need for further research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.