ArticlePancreas2012
Ethanol administration impairs pancreatic repair after injury.
Article in Pancreas, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Effects of Alcohol Consumption on Various Systems of the Human Body: A Systematic Review.Cureus · 2022Review
- Natural Recovery by the Liver and Other Organs after Chronic Alcohol Use.Alcohol research : current reviews · 2021Review
- NOTCH and Esophageal Squamous Cell Carcinoma.Advances in experimental medicine and biology · 2021Review
- Alcohol Intoxication and the Postburn Gastrointestinal Hormonal Response.Journal of burn care & research : official publication of the American Burn Association · 2019Article
- Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis.Scientific reports · 2019Article
- The Involvement of Acetaldehyde in Ethanol-Induced Cell Cycle Impairment.Biomolecules · 2016Article
- Alcoholic pancreatitis: New insights into the pathogenesis and treatment.World journal of gastrointestinal pathophysiology · 2016Review
- An optimised mouse model of chronic pancreatitis with a combination of ethanol and cerulein.Central-European journal of immunology · 2016Article
- Molecular mechanisms of ethanol-associated oro-esophageal squamous cell carcinoma.Cancer letters · 2015Review
- Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats.World journal of gastroenterology · 2015Article
- Molecular mechanisms of alcohol associated pancreatitis.World journal of gastrointestinal pathophysiology · 2014Review
- Endoscopic stent therapy in patients with chronic pancreatitis: a 5-year follow-up study.World journal of gastroenterology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesAlcohol abuse is one of the most common factors associated with acute and chronic pancreatitis. Although it is evident that alcohol abuse can have an important role in the development of pancreatitis, it does not seem that alcohol abuse alone is responsible for this disease. We investigated the involvement of ethanol in the impairment of pancreatic repair after induction of pancreatitis.
methodsA biologically relevant mouse model of alcoholic pancreatitis, combining long-term ethanol consumption and coxsackievirus infection, was used to investigate the effects of ethanol on pancreatic regeneration. Tissues were harvested and analyzed by reverse transcription-polymerase chain reaction and immunoblot.
resultsThese studies demonstrate that long-term ethanol consumption impairs the structural repair of the exocrine pancreas. This is accompanied by a delay in the restitution of lipase expression. In addition, impaired expression of the critical pancreatic transcription factors, PDX1 and PTF1, and the mediator of Notch signaling, HES1, was observed.
conclusionsLong-term ethanol consumption impairs the structural repair and functional restitution of the pancreas after severe injury. These impairments may, in part, be explained by the impaired expression of factors important in the development and maintenance of the exocrine pancreas. Impaired pancreatic regeneration may have a role in the pathogenesis of alcoholic pancreatitis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.