ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2012
Reproducibility of cerebral blood flow assessment using a quantitative SPECT reconstruction program and split-dose 123I-iodoamphetamine in institutions with different γ-cameras and collimators.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 22 citations in OpenAlex.
- Impact of body weight on arterial partition coefficient estimation inAnnals of nuclear medicine · 2026Article
- Stepwise Improvement of Cerebral Hemodynamics in Staged Angioplasty for Carotid Artery Stenosis.Neurologia medico-chirurgica · 2025Article
- Outcome prediction of pediatric moyamoya disease using midterm cerebral blood flow measured between staged anastomoses.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Basal and Acetazolamide Brain Perfusion SPECT in Internal Carotid Artery Stenosis.Nuclear medicine and molecular imaging · 2020Review
- Leptomeningeal Collaterals Strongly Correlate with Reduced Cerebrovascular Reactivity Measured by Acetazolamide-challenged Single-photon Emission Computed Tomography Using a Stereotactic Extraction Estimation Analysis in Patients with Unilateral Internal Carotid Artery Stenosis.Internal medicine (Tokyo, Japan) · 2017Article
- Multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification: An IAEA phantom study.Zeitschrift fur medizinische Physik · 2017Article
- A robust conversion method of radioactivities between plastic and NaI scintillation well counters for long-term quality control and quality assurance.EJNMMI physics · 2016Article
- Reduction in camera-specific variability in [(123)I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls.European journal of nuclear medicine and molecular imaging · 2016Article
- In vivo quantification of (177)Lu with planar whole-body and SPECT/CT gamma camera imaging.EJNMMI physics · 2015Article
- Cognitive Dysfunction Survey of the Japanese Patients with Moyamoya Disease (COSMO-JAPAN Study): study protocol.Neurologia medico-chirurgica · 2015Review
- Quantitative assessment of rest and acetazolamide CBF using quantitative SPECT reconstruction and sequential administration of (123)I-iodoamphetamine: comparison among data acquired at three institutions.Annals of nuclear medicine · 2014Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single photon emission computed tomography (SPECT) is used widely in clinical studies. However, the technique requires image reconstruction and the methods for correcting scattered radiation and absorption are not standardized among SPECT procedures. Therefore, quantitation of cerebral blood flow (CBF) may not be constant across SPECT models. The quantitative SPECT (QSPECT) software package has been developed for standardization of CBF. Using the QSPECT/dual-table autoradiographic (DTARG) method, CBF and cerebral vascular reactivity (CVR) at rest and after acetazolamide challenge can be evaluated using (123)I-iodoamphetamine in a single SPECT session. In this study, we examined the reproducibility of quantitative regional CBF and CVR in QSPECT/DTARG using different SPECT models at two facilities. The subjects were nine patients with chronic cerebral ischemic disease who underwent QSPECT/DTARG at both facilities with use of different γ-cameras and collimators. There were significant correlations for CBF at rest and after acetazolamide challenge measured at the two facilities. The consistency of the CBFs of the patients measured at the two facilities were good in all cases. Our results show that CBF measured by QSPECT/DTARG in the same patients is reproducible in different SPECT models. This indicates that standardized evaluation of CBF can be performed in large multicenter studies.
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