ArticleCancer letters2012
Imaging-guided curative surgical resection of pancreatic cancer in a xenograft mouse model.
Article in Cancer letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Immunomodulation of Pancreatic Cancer via Inhibition of SUMOylation and the CD155/TIGIT Pathway.Molecular cancer therapeutics · 2026Article
- A microscopically assisted limited colectomy mouse model of early colon cancer.Animal models and experimental medicine · 2026Article
- Convergent insulin and TGF-β signalling drives cancer cachexia by promoting aberrant fat body ECM accumulation in a Drosophila tumour model.EMBO reports · 2023Article
- A prognostic model based on tumor microenvironment-related lncRNAs predicts therapy response in pancreatic cancer.Functional & integrative genomics · 2023Article
- Tumor cell anabolism and host tissue catabolism-energetic inefficiency during cancer cachexia.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Three categories of similarities between the placenta and cancer that can aid cancer treatment: Cells, the microenvironment, and metabolites.Frontiers in oncology · 2022Review
- The Potential Therapeutic Role of Exosomal MicroRNA-520b Derived from Normal Fibroblasts in Pancreatic Cancer.Molecular therapy. Nucleic acids · 2020Article
- Understanding cachexia in the context of metastatic progression.Nature reviews. Cancer · 2020Review
- ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells.Gastroenterology · 2019Article
- Isolation of circulating tumor cells in pancreatic cancer patients by immunocytochemical assay.Journal of clinical laboratory analysis · 2018Article
- Familial Pancreatic Cancer and the Future of Directed Screening.Gut and liver · 2017Review
- Concurrent chemotherapy alone versus irreversible electroporation followed by chemotherapy on survival in patients with locally advanced pancreatic cancer.Medical oncology (Northwood, London, England) · 2017Article
- Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy.Molecular cancer therapeutics · 2016Article
- Dual Targeting of Tissue Factor and CD105 for Preclinical PET Imaging of Pancreatic Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Article
- The miRacle in Pancreatic Cancer by miRNAs: Tiny Angels or Devils in Disease Progression.International journal of molecular sciences · 2016Review
- Characterization of the role of the photosensitizer, deuteporfin, in the detection of lymphatic metastases in a pancreatic cancer xenograft model.Oncology letters · 2015Article
- Dual-imaging model of SQUID biosusceptometry for locating tumors targeted using magnetic nanoparticles.Journal of nanobiotechnology · 2015Article
- LRH1 promotes pancreatic cancer metastasis.Cancer letters · 2014Article
- Risk factors and therapeutic targets in pancreatic cancer.Frontiers in oncology · 2013Review
- Study human pancreatic cancer in mice: how close are they?Biochimica et biophysica acta · 2013Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Pancreatic cancer is the fourth leading cause of cancer related deaths in North America. The poor survival statistics are due to the fact that there are no reliable tests for early diagnosis and no effective therapies once metastasis has occurred. Surgical resection is the only curative treatment for pancreatic cancer; however, only less than 15% of the patients are eligible for surgery at diagnosis. New therapies are urgently needed for this malignant disease. And combinational therapy including surgery, chemotherapy and molecular targeted therapy may further improve the efficacy of individual therapies. However, a reliable mouse model which mimics the human disease and can be used for testing the surgical treatment and surgery-based combinational therapy is not available. In this study, we have established a mouse model for curative surgical resection of pancreatic cancer. Human pancreatic cancer cells were used to create orthotopic xenografts in nude mice, distal pancreatectomy was performed using imaging-guided technology to remove the pancreatic tumors, and sham surgery was performed in the control group. All mice survived the operation and no complication was observed. Surgical resection at early stage improved the survival rate and quality of life of the mice compared with the sham surgery and surgical resection at the late stage. If combined with other therapies such as chemotherapy and molecular targeted therapy, it could further improve the outcome of pancreatic cancer. This mouse model is a useful tool to study the surgical therapy and the tumor recurrence of pancreatic cancer, and could potentially impact the therapeutic choices for this deadly disease.
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