ReviewCurrent opinion in clinical nutrition and metabolic care2012
Clock regulation of dietary lipid absorption.
Review in Current opinion in clinical nutrition and metabolic care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- An mHealth-Supported antenatal lifestyle intervention may be associated with improved maternal sleep in pregnancy: Secondary analysis from the PEARS trial.BJOG : an international journal of obstetrics and gynaecology · 2022Trial
- Agomelatine Mitigates Kidney Damage in Obese Insulin-Resistant Rats by Inhibiting Inflammation and Necroptosis via the TNF-α/NF-ĸB/p-RIPK3 Pathway.International journal of molecular sciences · 2025Article
- Correlating excessive daytime sleepiness with body mass index, waist circumference, and lipid profile in shift workers.Saudi medical journal · 2022Article
- The relationships of shift work, hair cortisol concentration and dyslipidaemia: a cohort study in China.BMC public health · 2022Article
- Human intestinal lipid storage through sequential meals reveals faster dinner appearance is associated with hyperlipidemia.JCI insight · 2021Observational
- Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases.Advances in experimental medicine and biology · 2020Review
- Circadian physiology of metabolism.Science (New York, N.Y.) · 2016Review
- Separate and Joint Associations of Shift Work and Sleep Quality with Lipids.Safety and health at work · 2016Article
- Short-term circadian disruption impairs bile acid and lipid homeostasis in mice.Cellular and molecular gastroenterology and hepatology · 2015Article
- Melatonin, noncoding RNAs, messenger RNA stability and epigenetics--evidence, hints, gaps and perspectives.International journal of molecular sciences · 2014Review
- Ribonucleoprotein complexes that control circadian clocks.International journal of molecular sciences · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewTo summarize the new knowledge about the regulation of dietary lipid absorption by circadian locomotor output cycles kaput (Clock) and Nocturnin. RECENT
findingsRecent findings have shown that Clock and Nocturnin, proteins involved in circadian regulation, play an important role in the regulation of dietary lipid absorption. Clock deficiency increases, whereas Nocturnin deficiency decreases lipid absorption. Clock plays a role in turning off the genes involved in lipid absorption at the onset of the day. Molecular studies revealed that Clock binds to the promoter of small heterodimer partner to enhance its transcription. When levels are high, small heterodimer partner interacts with the transcription factors associated with the promoter of microsomal triglyceride transfer protein to repress transcription. Reduced microsomal triglyceride transfer protein levels are correlated with low intestinal lipid absorption and plasma lipid levels. In contrast, Nocturnin assists in lipid absorption by regulating their partitioning in different intracellular compartments. SUMMARY: Clock and Nocturnin regulate lipid absorption involving different mechanisms. It is likely that other clock genes also modulate lipid absorption and plasma lipid levels.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.