ReviewThe Proceedings of the Nutrition Society2012
Neural and metabolic regulation of macronutrient intake and selection.
Review in The Proceedings of the Nutrition Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 86 citations in OpenAlex.
- Meal sugar-protein balance determines postprandial FGF21 response in humans.American journal of physiology. Endocrinology and metabolism · 2023Trial
- Trial
- Review
- Impact of a soybean oil-enriched diet on metabolic parameters in a chick model of childhood obesity.Veterinary research forum : an international quarterly journal · 2026Article
- FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling.bioRxiv : the preprint server for biology · 2024Article
- Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis.Nature communications · 2024Article
- Longitudinal assessment of brain structure and behaviour in youth with rapid weight gain: Potential contributing causes and consequences.Pediatric obesity · 2023Article
- Macronutrient intake: Hormonal controls, pathological states, and methodological considerations.Appetite · 2023Review
- Hindbrain circuits in the control of eating behaviour and energy balance.Nature metabolism · 2022Review
- The gut microbiome influences host diet selection behavior.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Fibroblast Growth Factor 21 Facilitates the Homeostatic Control of Feeding Behavior.Journal of clinical medicine · 2022Review
- Protein Appetite at the Interface between Nutrient Sensing and Physiological Homeostasis.Nutrients · 2021Review
- Protein Appetite Drives Macronutrient-Related Differences in Ventral Tegmental Area Neural Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Multimodal brain predictors of current weight and weight gain in children enrolled in the ABCD study ®.Developmental cognitive neuroscience · 2021Article
- Genomic analysis of diet composition finds novel loci and associations with health and lifestyle.Molecular psychiatry · 2021Article
- Age-dependent effects of protein restriction on dopamine release.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- What Should I Eat and Why? The Environmental, Genetic, and Behavioral Determinants of Food Choice: Summary from a Pennington Scientific Symposium.Obesity (Silver Spring, Md.) · 2020Review
- Protein intake is more stable than carbohydrate or fat intake across various US demographic groups and international populations.The American journal of clinical nutrition · 2020Article
- FGF21 and the Physiological Regulation of Macronutrient Preference.Endocrinology · 2020Review
- Protein Valuation in Food Choice Is Positively Associated with Lean Mass in Older Adults.The Journal of nutrition · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
There is considerable disagreement regarding what constitutes a healthy diet. Ever since the influential work of Cannon and Richter, it was debated whether the 'wisdom of the body' will automatically direct us to the foods we need for healthy lives or whether we must carefully learn to eat the right foods, particularly in an environment of plenty. Although it is clear that strong mechanisms have evolved to prevent consumption of foods that have previously made us sick, it is less clear whether reciprocal mechanisms exist that reinforce the consumption of healthy diets. Here, we review recent progress in providing behavioural evidence for the regulation of intake and selection of proteins, carbohydrates and fats. We examine new developments in sensory physiology enabling recognition of macronutrients both pre- and post-ingestively. Finally, we propose a general model for central neural processing of nutrient-specific appetites. We suggest that the same basic neural circuitry responsible for the homoeostatic regulation of total energy intake is also used to control consumption of specific macro- and micronutrients. Similar to salt appetite, specific appetites for other micro- and macronutrients may be encoded by unique molecular changes in the hypothalamus. Gratification of such specific appetites is then accomplished by engaging the brain motivational system to assign the highest reward prediction to exteroceptive cues previously associated with consuming the missing ingredient. A better understanding of these nutrient-specific neural processes could help design drugs and behavioural strategies that promote healthier eating.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.