ArticleNature communications2012
Evolution of a tissue-specific silencer underlies divergence in the expression of pax2 and pax8 paralogues.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 42 citations in OpenAlex.
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- Adrenergic receptor signaling induced by Klf15, a regulator of regeneration enhancer, promotes kidney reconstruction.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.The Journal of experimental medicine · 2021Article
- Independent pseudogenizations and losses of sox15 during amniote diversification following asymmetric ohnolog evolution.BMC ecology and evolution · 2021Article
- Regeneration enhancers: A clue to reactivation of developmental genes.Development, growth & differentiation · 2020Review
- Attenuated Fgf Signaling Underlies the Forelimb Heterochrony in the Emu Dromaius novaehollandiae.Current biology : CB · 2019Article
- Modeling congenital kidney diseases inDisease models & mechanisms · 2019Review
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- The voltage sensing phosphatase (VSP) localizes to the apical membrane of kidney tubule epithelial cells.PloS one · 2019Article
- Inference of the ancestral vertebrate phenotype through vestiges of the whole-genome duplications.Briefings in functional genomics · 2018Review
- A shift in anterior-posterior positional information underlies the fin-to-limb evolution.eLife · 2015Article
- Heterozygous triplication of upstream regulatory sequences leads to dysregulation of matrix metalloproteinase 19 in patients with cavitary optic disc anomaly.Human mutation · 2015Article
- Evolution of transcriptional enhancers and animal diversity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Recent studies underscore a role for the differential degeneration of enhancers in the evolutionary diversification of paralogue expression. However, no one has reported evidence for the involvement of innovative cis-regulatory changes. Here we show that silencer innovation diversified expression of the vertebrate paralogues, pax2 and pax8. pax2 shows multi-tissue expression, as does the ancestral amphioxus orthologue, pax2/5/8, whereas pax8 expression localizes to a subset of pax2-expressing tissues. We reveal that both pax2 and pax8 retain ancestral enhancers capable of directing pax2-like, multi-tissue expression. However, a silencer within the pax8 proximal promoter suppresses pleiotropic enhancer activity outside the pax8-expressing tissues. In contrast, the combination of the pax2 proximal promoter with either the pax8 or pax2 enhancer recapitulates pax2-like expression, as in the amphioxus pax2/5/8 promoter. We propose that silencer innovation, rather than enhancer degeneration, was crucial for the divergent expression of paralogues with pleiotropic enhancers inherited from their common progenitor.
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