Evidence map›Paper›PMID 22617278›Full record

Trial reportEuropean journal of clinical nutrition2012

Preoperative immunonutrition in patients at nutritional risk: results of a double-blinded randomized clinical trial.

M Hübner, Y Cerantola, F Grass, P C Bertrand, M Schäfer, N Demartines

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 5 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 5 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Pooled it
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  4. [Application Effect of Fast Track Surgery for Patients with Lung Cancer: 
A Meta-analysis].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2016
    Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Review
  9. Article
  10. [Preoperative bowel conditioning].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2019
    Review
  11. Article
  12. Article
  13. The Effect of Immunonutrition on Veterans Undergoing Major Surgery for Gastrointestinal Cancer.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2018
    Article
  14. Article
  15. Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

M HübnerDepartment of Visceral Surgery, University Hospital CHUV, Lausanne, Switzerland.
Y Cerantola
F Grass
P C Bertrand
M Schäfer
N Demartines
University Hospital of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesTo evaluate the impact of preoperative immunonutrition (IN) on postoperative morbidity in patients at risk of malnutrition undergoing major gastrointestinal (GI) surgery. SUBJECTS/

methodsThe combination of malnutrition and major GI surgery entails high morbidity. The Nutritional Risk Score (NRS) reliably identifies patients who need preoperative nutrition; the optimal nutritional formula for these patients still needs to be defined. In all, 152 patients with a NRS≥3 and undergoing elective major GI surgery were randomized between IN or isocaloric-isonitrogenous nutrition (ICN) given for 5 days preoperatively. Patients and caregivers were blinded for the allocated intervention. Thirty days complication rate was the primary endpoint. Infections, length of hospital stay and compliance were considered as secondary outcomes.

resultsOverall, 145 patients were available for analysis; the 73 patients in the IN group matched well with the 72 ICN patients with regards to patient's and surgical characteristics. In all, 39 IN and 33 ICN patients experienced a total of 48 and 50 postoperative complications, respectively (P=0.723). Both groups did not differ significantly concerning infectious (13 vs 9) complications. Independent risk factors for overall complications were malignant disease (odds ratio (OR)=4.304; confidence interval (CI) 1.317-14.002) and operative time (OR=1.004; CI 1.000-1.008).

conclusionIn patients at nutritional risk, complications, infections and hospital stay after major GI surgery were comparable regardless of preoperative supplementation with IN or ICN.

Indexed as

DietEnteral NutritionAgedAged, 80 and overConfidence IntervalsCross InfectionDouble-Blind MethodElective Surgical ProceduresFemaleGastrointestinal DiseasesHumansIncidenceLength of StayMaleMalnutritionMiddle Aged

Identifiers

PMID22617278
OpenAlexW1991769248

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.