Evidence map›Paper›PMID 22617227›Full record

GuidelineClinical pharmacology and therapeutics2012

The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy.

R A Wilke, L B Ramsey, S G Johnson, W D Maxwell, H L McLeod, D Voora, R M Krauss, D M Roden, Q Feng, R M Cooper-Dehoff and 5 more

Open access · bronzeAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Clinical pharmacology and therapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 16 pooled it
42.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 16 syntheses or guidelines pooled it, 325 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Is a PCSK9 Inhibitor Right for Your Patient? A Review of Treatment Data for Individualized Therapy.International journal of environmental research and public health · 2022
    Pooled it
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  5. Genomewide Association Study of Simvastatin Pharmacokinetics.Clinical pharmacology and therapeutics · 2022
    Pooled it
  6. The role ofExpert review of clinical pharmacology · 2022
    Pooled it
  7. Guideline
  8. Pooled it
  9. A comprehensive review and meta-analysis of risk factors for statin-induced myopathy.European journal of clinical pharmacology · 2018 · on this map
    Pooled it
  10. Pooled it
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  12. Genetic factors affecting statin concentrations and subsequent myopathy: a HuGENet systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2014
    Pooled it
  13. Pooled it
  14. Guideline
  15. Pooled it
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  17. Trial
  18. Trial
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102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 3 countries.

R A WilkeOates Institute for Experimental Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. russell.a.wilke@vanderbilt.edu
L B Ramsey
S G Johnson
W D Maxwell
H L McLeod
D Voora
R M Krauss
D M Roden
Q Feng
R M Cooper-Dehoff
L Gong
T E Klein
M Wadelius
M Niemi
Clinical Pharmacogenomics Implementation Consortium (CPIC)
Stanford University · USVanderbilt University Medical Center · USDuke University · USHelsinki University Hospital · FISt. Jude Children's Research Hospital · USUniversity of Colorado Denver · USUniversity of Florida · USUniversity of North Carolina at Chapel Hill · USUppsala University · SEVanderbilt University · US

Funding

PharmGKB: pharmacogenomics knowledge for precision medicineR24GM061374 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO, KLEIN, TERI ELLEN · 2010 to 2018
$25.2M
Pharmacogenomics and Risk of Cardiovascular DiseaseU01HL069757 · NHLBI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KRAUSS, RONALD M · 2001 to 2009
$24.7M
Pharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4M
Vanderbilt Genome Electronic Records ProjectU01HG006378 · NHGRI · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2011 to 2014
$4.0M
Pharmacogenetics of obesity and endocannabinergic modulation (POEM)R01DK080007 · NIDDK · VANDERBILT UNIVERSITY · PI WILKE, RUSSELL A. · 2009 to 2012
$1.2M
NHGRI NIH HHS U01 HG006378NHGRI NIH HHS U01HG006378NHLBI NIH HHS K23HL086556NHLBI NIH HHS U01 HL069757NHLBI NIH HHS U01HL069757NHLBI NIH HHS U19 HL065962NHLBI NIH HHS U19HL065962NIDDK NIH HHS R01 DK080007NIDDK NIH HHS R01DK080007NIGMS NIH HHS R24 GM061374NIGMS NIH HHS R24 GM61374
6 · The paper itself

Abstract

Cholesterol reduction from statin therapy has been one of the greatest public health successes in modern medicine. Simvastatin is among the most commonly used prescription medications. A non-synonymous coding single-nucleotide polymorphism (SNP), rs4149056, in SLCO1B1 markedly increases systemic exposure to simvastatin and the risk of muscle toxicity. This guideline explores the relationship between rs4149056 (c.521T>C, p.V174A) and clinical outcome for all statins. The strength of the evidence is high for myopathy with simvastatin. We limit our recommendations accordingly.

Indexed as

Hydroxymethylglutaryl-CoA Reductase InhibitorsMuscular DiseasesPolymorphism, Single NucleotideSimvastatinDrug PrescriptionsHumansLiver-Specific Organic Anion Transporter 1Organic Anion TransportersPharmacogeneticsPrecision MedicineRisk AssessmentRisk FactorsHydroxymethylglutaryl-CoA Reductase InhibitorsLiver-Specific Organic Anion Transporter 1Organic Anion TransportersSimvastatinSLCO1B1 protein, human

Identifiers

PMID22617227
PMCPMC3384438
OpenAlexW2105311148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.