ReviewFEBS letters2012
Abi1, a critical molecule coordinating actin cytoskeleton reorganization with PI-3 kinase and growth signaling.
Review in FEBS letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Loss of Wave1 gene defines a subtype of lethal prostate cancer.Oncotarget · 2015Pooled it
- Systematic AI-assisted screening of the cadhesome to map epithelial monolayer mechanics.Cell communication and signaling : CCS · 2026Article
- A pore-forming toxin initiates ABI1 complex switching to promote bacterial cell-to-cell spread.Nature communications · 2026Article
- Programmed cell death-related ABI1 is a critical mediator of abdominal aortic aneurysm.European journal of medical research · 2024Article
- GTP Signaling Links Metabolism, DNA Repair, and Responses to Genotoxic Stress.Cancer discovery · 2024Article
- Intra-promoter switch of transcription initiation sites in proliferation signaling-dependent RNA metabolism.Nature structural & molecular biology · 2023Article
- Article
- Circular dorsal ruffles disturb the growth factor-induced PI3K-AKT pathway in hepatocellular carcinoma Hep3B cells.Cell communication and signaling : CCS · 2022Article
- RBFOX2 is required for establishing RNA regulatory networks essential for heart development.Nucleic acids research · 2022Article
- Abi1 mediates airway smooth muscle cell proliferation and airway remodeling via Jak2/STAT3 signaling.iScience · 2022Article
- The Neuron Navigators: Structure, function, and evolutionary history.Frontiers in molecular neuroscience · 2022Review
- Roles for 3' Phosphoinositides in Macropinocytosis.Sub-cellular biochemistry · 2022Article
- Abelson interactor 1 splice isoform-L plays an anti-oncogenic role in colorectal carcinoma through interactions with WAVE2 and full-length Abelson interactor 1.World journal of gastroenterology · 2021Article
- Effects and mechanisms of Eps8 on the biological behaviour of malignant tumours (Review).Oncology reports · 2021Review
- Pravastatin-induced changes in expression of long non-coding and coding RNAs in endothelial cells.Physiological reports · 2021Article
- PTEN suppresses epithelial-mesenchymal transition and cancer stem cell activity by downregulating Abi1.Scientific reports · 2020Article
- The Role of the Human CytomegalovirusViruses · 2020Review
- Distinctive roles of Abi1 in regulating actin-associated proteins during human smooth muscle cell migration.Scientific reports · 2020Article
- Systematic Analyses of the Differentially Expressed Alternative Splicing Events in Gastric Cancer and Its Clinical Significance.Frontiers in genetics · 2020Article
- On the existence of endocytosis driven by membrane phase separations.Biochimica et biophysica acta. Biomembranes · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Coordination of actin cytoskeletal reorganization with growth and proliferation signals is a key cellular process that is not fully understood. PI-3 kinase is one of the central nodes for distributing growth and proliferation signals downstream from growth factor receptors to the nucleus. Although PI-3 kinase function has been associated with actin cytoskeleton remodeling, satisfactory explanations of the mechanisms mediating this regulation have been elusive. Here we propose that interaction of the Abi1 protein with the p85 regulatory subunit of PI-3 kinase represents the link between growth receptor signaling and actin cytoskeleton remodeling. This function of Abi1, which involves WAVE complex, was initially observed in macropinocytosis, and may explain the coincident dysregulation of PI-3 kinase and actin cytoskeleton in cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.