Evidence map›Paper›PMID 22616478›Full record

ReviewBiotechnology & genetic engineering reviews2012

Expression of complete metabolic pathways in transgenic plants.

Alexander Krichevsky, Adi Zaltsman, Lisa King, Vitaly Citovsky

Abstract readReview
In one paragraph

Review in Biotechnology & genetic engineering reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexander KrichevskyDepartment of Biochemistry and Cell Biology, State University of New York, Stony Brook, NY 11794, USA. vitaly.citovsky@stonybrook.edu
Adi Zaltsman
Lisa King
Vitaly Citovsky

Funding

TRANSPORT THROUGH PLASMODESMATAR01GM050224 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI CITOVSKY, VITALY H · 1994 to 2020
$5.7M
NIGMS NIH HHS R01 GM050224
6 · The paper itself

Abstract

Plant genetic engineering emerged as a methodology to introduce only few transgenes into the plant genome. Following fast-paced developments of the past few decades, engineering of much larger numbers of transgenes became a reality, allowing to introduce full metabolic pathways from other organisms into plants and generate transgenics with startling new traits. From the advent of the classical plant genetic engineering, the transgenes were introduced into the nuclear genome of the plant cell, and this strategy still is quite successful when applied to few transgenes. However, for introducing large number of transgenes, we advocate that the chloroplast genome is a superior choice, especially for engineering of new complete metabolic pathways into plants. The ability to genetically engineer plants with complex and fully functional metabolic pathways from other organisms bears a substantial promise in generation of pharmaceuticals, i.e., biopharming, and new agricultural crops with that traits never existed before, leading to enhancement in quality of human life.

Indexed as

BiotechnologyChloroplastsCrops, AgriculturalGenetic EngineeringGenetic VectorsGenome, PlantHumansMetabolic Networks and PathwaysPlant CellsPlants, Genetically ModifiedTransformation, GeneticTransgenes

Identifiers

PMID22616478
PMCPMC9470375

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.