ArticlePloS one2012
A comprehensive breath plume model for disease transmission via expiratory aerosols.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- An Assessment of Airborne Bacteria and Fungi in the Female Dormitory Environment: Level, Impact Factors and Dose Rate.International journal of environmental research and public health · 2022Article
- End-to-end design of wearable sensors.Nature reviews. Materials · 2022Review
- Article
- Article
- Non-respiratory particles emitted by guinea pigs in airborne disease transmission experiments.Scientific reports · 2021Article
- Effect of Train-Induced Wind on the Transmission of COVID-19: A New Insight into Potential Infectious Risks.International journal of environmental research and public health · 2021Article
- Revisiting physical distancing threshold in indoor environment using infection-risk-based modeling.Environment international · 2021Article
- Effect of relative humidity on hydrogen peroxide production in water droplets.QRB discovery · 2021Article
- High-Fidelity Simulation of Pathogen Propagation, Transmission and Mitigation in the Built Environment.Archives of computational methods in engineering : state of the art reviews · 2021Article
- The transmission of SARS-CoV-2 is likely comodulated by temperature and by relative humidity.PloS one · 2021Article
- Detailed simulation of viral propagation in the built environment.Computational mechanics · 2020Article
- Mechanistic insights into the effect of humidity on airborne influenza virus survival, transmission and incidence.Journal of the Royal Society, Interface · 2019Article
- Influenza Virus Infectivity Is Retained in Aerosols and Droplets Independent of Relative Humidity.The Journal of infectious diseases · 2018Article
- Influenza Virus Infection Model With Density Dependence Supports Biphasic Viral Decay.Frontiers in microbiology · 2018Article
- Crossing the scale from within-host infection dynamics to between-host transmission fitness: a discussion of current assumptions and knowledge.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Turbulent dispersion via fan-generated flows.Physics of fluids (Woodbury, N.Y. : 1994) · 2014Article
- How sticky should a virus be? The impact of virus binding and release on transmission fitness using influenza as an example.Journal of the Royal Society, Interface · 2014Article
- ABSL-4 aerobiology biosafety and technology at the NIH/NIAID integrated research facility at Fort Detrick.Viruses · 2014Article
- A multi-scale analysis of influenza A virus fitness trade-offs due to temperature-dependent virus persistence.PLoS computational biology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The peak in influenza incidence during wintertime in temperate regions represents a longstanding, unresolved scientific question. One hypothesis is that the efficacy of airborne transmission via aerosols is increased at lower humidities and temperatures, conditions that prevail in wintertime. Recent work with a guinea pig model by Lowen et al. indicated that humidity and temperature do modulate airborne influenza virus transmission, and several investigators have interpreted the observed humidity dependence in terms of airborne virus survivability. This interpretation, however, neglects two key observations: the effect of ambient temperature on the viral growth kinetics within the animals, and the strong influence of the background airflow on transmission. Here we provide a comprehensive theoretical framework for assessing the probability of disease transmission via expiratory aerosols between test animals in laboratory conditions. The spread of aerosols emitted from an infected animal is modeled using dispersion theory for a homogeneous turbulent airflow. The concentration and size distribution of the evaporating droplets in the resulting "Gaussian breath plume" are calculated as functions of position, humidity, and temperature. The overall transmission probability is modeled with a combination of the time-dependent viral concentration in the infected animal and the probability of droplet inhalation by the exposed animal downstream. We demonstrate that the breath plume model is broadly consistent with the results of Lowen et al., without invoking airborne virus survivability. The results also suggest that, at least for guinea pigs, variation in viral kinetics within the infected animals is the dominant factor explaining the increased transmission probability observed at lower temperatures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.