ArticlePloS one2012
Association analysis of the extended MHC region in celiac disease implicates multiple independent susceptibility loci.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.Nature medicine · 2015Pooled it
- Regulation of Chemokine Signal Integration by Activator of G-Protein Signaling 4 (AGS4).The Journal of pharmacology and experimental therapeutics · 2017Article
- Interactions within the MHC contribute to the genetic architecture of celiac disease.PloS one · 2017Article
- Association between rs2294020 in X-linked CCDC22 and susceptibility to autoimmune diseases with focus on systemic lupus erythematosus.Immunology letters · 2017Article
- HLA-DPB1*04:01 Protects Genetically Susceptible Children from Celiac Disease Autoimmunity in the TEDDY Study.The American journal of gastroenterology · 2015Article
- Appropriate clinical use of human leukocyte antigen typing for coeliac disease: an Australasian perspective.Internal medicine journal · 2015Article
- Genomic prediction of celiac disease targeting HLA-positive individuals.Genome medicine · 2015Article
- TNFA Haplotype Genetic Testing Improves HLA in Estimating the Risk of Celiac Disease in Children.PloS one · 2015Article
- Association between the MYO9B polymorphisms and celiac disease risk: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Principal component analysis characterizes shared pathogenetics from genome-wide association studies.PLoS computational biology · 2014Article
- US perspective on gluten-related diseases.Clinical and experimental gastroenterology · 2014Review
- Accounting for eXentricities: analysis of the X chromosome in GWAS reveals X-linked genes implicated in autoimmune diseases.PloS one · 2014Article
- Article
- The role of HLA DQ2 and DQ8 in dissecting celiac-like disease in common variable immunodeficiency.Journal of clinical immunology · 2013Article
- Celiac disease: a challenging disease for pharmaceutical scientists.Pharmaceutical research · 2013Article
- XWAS: A Software Toolset for Genetic Data Analysis and Association Studies of the X Chromosome.The Journal of heredityArticle
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
Celiac disease is a common autoimmune disease caused by sensitivity to the dietary protein gluten. Forty loci have been implicated in the disease. All disease loci have been characterized as low-penetrance, with the exception of the high-risk genotypes in the HLA-DQA1 and HLA-DQB1 genes, which are necessary but not sufficient to cause the disease. The very strong effects from the known HLA loci and the genetically complex nature of the major histocompatibility complex (MHC) have precluded a thorough investigation of the region. The purpose of this study was to test the hypothesis that additional celiac disease loci exist within the extended MHC (xMHC). A set of 1898 SNPs was analyzed for association across the 7.6 Mb xMHC region in 1668 confirmed celiac disease cases and 517 unaffected controls. Conditional recursive partitioning was used to create an informative indicator of the known HLA-DQA1 and HLA-DQB1 high-risk genotypes that was included in the association analysis to account for their effects. A linkage disequilibrium-based grouping procedure was utilized to estimate the number of independent celiac disease loci present in the xMHC after accounting for the known effects. There was significant statistical evidence for four new independent celiac disease loci within the classic MHC region. This study is the first comprehensive association analysis of the xMHC in celiac disease that specifically accounts for the known HLA disease genotypes and the genetic complexity of the region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.