ArticlePloS one2012
Photic desynchronization of two subgroups of circadian oscillators in a network model of the suprachiasmatic nucleus with dispersed coupling strengths.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Network Structure of the Master Clock Is Important for Its Primary Function.Frontiers in physiology · 2021Review
- Coherency of circadian rhythms in the SCN is governed by the interplay of two coupling factors.PLoS computational biology · 2018Article
- The effects of non-self-sustained oscillators on the en-trainment ability of the suprachiasmatic nucleus.Scientific reports · 2016Article
- The synchronization of neuronal oscillators determined by the directed network structure of the suprachiasmatic nucleus under different photoperiods.Scientific reports · 2016Article
- Heterogeneity induces rhythms of weakly coupled circadian neurons.Scientific reports · 2016Article
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4 authors.
Funding
Abstract
The suprachiasmatic nucleus (SCN) is the master circadian clock in mammals and is composed of thousands of neuronal oscillators expressing different intrinsic periods. These oscillators form a coupled network with a free-running period around 24 h in constant darkness and entrainable to the external light-dark cycle (T cycle). Coupling plays an important role in setting the period of the network and its range of entrainment. Experiments in rats have shown that two subgroups of oscillators within the SCN, a ventrolateral (VL) subgroup that receives photic input and a dorsomedial (DM) subgroup that is coupled to VL, can be desynchronized under a short (22-h) T cycle, with VL entrained to the cycle and DM free-running. We use a modified Goodwin model to understand how entrainment of the subgroups to short (22-h) and long (26-h) T cycles is influenced by light intensity, the proportion of neurons that receives photic input, and coupling heterogeneity. We find that the model's critical value for the proportion of photically-sensitive neurons is in accord with actual experimental estimates, while the model's inclusion of dispersed coupling can account for the experimental observation that VL and DM desynchronize more readily under the 22-h than under the 26-h T cycle. Heterogeneous intercellular coupling within the SCN is likely central to the generation of complex behavioral patterns.
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