ArticlePloS one2012
Genome-wide association studies identified three independent polymorphisms associated with α-tocopherol content in maize kernels.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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Who cites it
80 citing papers in PubMed, 147 citations in OpenAlex.
- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
- Vitamin E in Plants: Biosynthesis Pathways, Biofortification Strategies, and Regulatory Dynamics.International journal of molecular sciences · 2025Review
- Precise engineering of gene expression by editing plasticity.Genome biology · 2025Article
- Enrichment of Vitamin A and Vitamin E in Sweet Corn Kernels Through Genomics-Assisted Introgression of Mutant Version of crtRB1 and vte4 Genes.Applied biochemistry and biotechnology · 2025Article
- Overexpression of ZmSPS2 increases α/γ-tocopherol ratio to improve maize nutritional quality.Plant biotechnology journal · 2025Article
- Development and Validation of Multiplex-PCR Assay forPlants (Basel, Switzerland) · 2025Article
- Article
- Genomic basis determining root system architecture in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- A Summary of Two Decades of QTL and Candidate Genes That Control Seed Tocopherol Contents in Maize (Genes · 2024Review
- Identification of Novel QTL for Mercury Accumulation in Maize Using an Enlarged SNP Panel.Genes · 2024Article
- HarnessingAntioxidants (Basel, Switzerland) · 2024Article
- Genomic prediction of tocochromanols in exotic-derived maize.The plant genome · 2023Article
- Leveraging prior biological knowledge improves prediction of tocochromanols in maize grain.The plant genome · 2023Article
- Enhancement of nutritional quality in maize kernel through marker-assisted breeding for vte4, crtRB1, and opaque2 genes.Journal of applied genetics · 2023Article
- Hybrid performance evaluation and genome-wide association analysis of root system architecture in a maize association population.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Combined population transcriptomic and genomic analysis reveals cis-regulatory differentiation of non-coding RNAs in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Unravelling the genetic framework associated with grain quality and yield-related traits in maize (Frontiers in genetics · 2023Article
- Characterization of crtRB1- and vte4-based biofortified sweet corn inbreds for seed vigour and physico-biochemical traits.Journal of applied genetics · 2022Article
- Natural polymorphism of ZmICE1 contributes to amino acid metabolism that impacts cold tolerance in maize.Nature plants · 2022Article
- Combining GWAS and TWAS to identify candidate causal genes for tocochromanol levels in maize grain.Genetics · 2022Article
20 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tocopherols are a class of four natural compounds that can provide nutrition and function as antioxidant in both plants and animals. Maize kernels have low α-tocopherol content, the compound with the highest vitamin E activity, thus, raising the risk of vitamin E deficiency in human populations relying on maize as their primary vitamin E source. In this study, two insertion/deletions (InDels) within a gene encoding γ-tocopherol methyltransferase, Zea mays VTE4 (ZmVTE4), and a single nucleotide polymorphism (SNP) located ~85 kb upstream of ZmVTE4 were identified to be significantly associated with α-tocopherol levels in maize kernels by conducting an association study with a panel of ~500 diverse inbred lines. Linkage analysis in three populations that segregated at either one of these three polymorphisms but not at the other two suggested that the three polymorphisms could affect α-tocopherol content independently. Furthermore, we found that haplotypes of the two InDels could explain ∼33% of α-tocopherol variation in the association panel, suggesting ZmVTE4 is a major gene involved in natural phenotypic variation of α-tocopherol. One of the two InDels is located within the promoter region and associates with ZmVTE4 transcript level. This information can not only help in understanding the underlying mechanism of natural tocopherol variations in maize kernels, but also provide valuable markers for marker-assisted breeding of α-tocopherol content in maize kernels, which will then facilitate the improvement of maize as a better source of daily vitamin E nutrition.
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