ArticlePloS one2012
Mathematical model of plasmid-mediated resistance to ceftiofur in commensal enteric Escherichia coli of cattle.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 80 citations in OpenAlex.
- Impact of treatment strategies on cephalosporin and tetracycline resistance gene quantities in the bovine fecal metagenome.Scientific reports · 2014Trial
- Interventions Targeting the Beef Feedlot Environment to Control Antimicrobial Resistance: A Mathematical Modelling Study.Zoonoses and public health · 2026Article
- Optimal Multi-Drug Therapies for Antimicrobial Resistance with Horizontal Transfer.Journal of optimization theory and applications · 2026Article
- Pulsed antibiotic release into the environment may foster the spread of antimicrobial resistance.FEMS microbiology ecology · 2025Article
- Quantifying trade-offs between therapeutic efficacy and resistance dissemination for enrofloxacin dose regimens in cattle.Scientific reports · 2024Article
- Quantifying trade-offs between therapeutic efficacy and resistance dissemination for enrofloxacin dose regimens in cattle.Research square · 2024Article
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- Contagious acquisition of antimicrobial resistance is critical for explaining emergence in western Canadian feedlots-insights from an agent-based modelling tool.Frontiers in veterinary science · 2024Article
- Modelling the impact of wastewater flows and management practices on antimicrobial resistance in dairy farms.npj antimicrobials and resistance · 2024Article
- Persistent effects of intramammary ceftiofur treatment on the gut microbiome and antibiotic resistance in dairy cattle.Animal microbiome · 2023Article
- The pharmacokinetic-pharmacodynamic modelling framework as a tool to predict drug resistance evolution.Microbiology (Reading, England) · 2023Article
- A mathematician's guide to plasmids: an introduction to plasmid biology for modellers.Microbiology (Reading, England) · 2023Review
- Standardization and evaluation of indicators for quantifying antimicrobial use on U.S. dairy farms.Frontiers in antibiotics · 2023Article
- Optimization and Validation of Dosage Regimen for Ceftiofur againstInternational journal of molecular sciences · 2022Article
- A Model to Investigate the Impact of Farm Practice on Antimicrobial Resistance in UK Dairy Farms.Bulletin of mathematical biology · 2021Article
- Impact of Ceftiofur Administration in Steers on the Prevalence and Antimicrobial Resistance ofMicroorganisms · 2021Article
- Antibiotics and Antibiotic Resistance Genes in Animal Manure - Consequences of Its Application in Agriculture.Frontiers in microbiology · 2021Review
- Mathematical Models of Plasmid Population Dynamics.Frontiers in microbiology · 2021Review
- Transcriptome changes and polymyxin resistance of acid-adapted Escherichia coli O157:H7 ATCC 43889.Gut pathogens · 2020Article
- Modeling transport of antibiotic resistant bacteria in aquatic environment using stochastic differential equations.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial use in food animals may contribute to antimicrobial resistance in bacteria of animals and humans. Commensal bacteria of animal intestine may serve as a reservoir of resistance-genes. To understand the dynamics of plasmid-mediated resistance to cephalosporin ceftiofur in enteric commensals of cattle, we developed a deterministic mathematical model of the dynamics of ceftiofur-sensitive and resistant commensal enteric Escherichia coli (E. coli) in the absence of and during parenteral therapy with ceftiofur. The most common treatment scenarios including those using a sustained-release drug formulation were simulated; the model outputs were in agreement with the available experimental data. The model indicated that a low but stable fraction of resistant enteric E. coli could persist in the absence of immediate ceftiofur pressure, being sustained by horizontal and vertical transfers of plasmids carrying resistance-genes, and ingestion of resistant E. coli. During parenteral therapy with ceftiofur, resistant enteric E. coli expanded in absolute number and relative frequency. This expansion was most influenced by parameters of antimicrobial action of ceftiofur against E. coli. After treatment (>5 weeks from start of therapy) the fraction of ceftiofur-resistant cells among enteric E. coli, similar to that in the absence of treatment, was most influenced by the parameters of ecology of enteric E. coli, such as the frequency of transfer of plasmids carrying resistance-genes, the rate of replacement of enteric E. coli by ingested E. coli, and the frequency of ceftiofur resistance in the latter.
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