ArticlePloS one2012
A primary survey on bryophyte species reveals two novel classes of nucleotide-binding site (NBS) genes.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 72 citations in OpenAlex.
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- Moss-pathogen interactions: a review of the current status and future opportunities.Frontiers in genetics · 2025Review
- Deciphering the landscape and evolutionary trajectory of NLR immune receptors in Dioscorea alata.Plant molecular biology · 2024Article
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- Characterization of theInternational journal of molecular sciences · 2024Article
- Comparative analysis, diversification, and functional validation of plant nucleotide-binding site domain genes.Scientific reports · 2024Article
- Analysis ofFrontiers in plant science · 2024Review
- Genome-wide identification of nucleotide-binding domain leucine-rich repeat (NLR) genes and their association with green peach aphid (Myzus persicae) resistance in peach.BMC plant biology · 2023Article
- An Overview of PRR- and NLR-Mediated Immunities: Conserved Signaling Components across the Plant Kingdom That Communicate Both Pathways.International journal of molecular sciences · 2022Review
- Genome-Wide Analysis ofFrontiers in genetics · 2022Article
- Mining germplasm panels and phenotypic datasets to identify loci for resistance to Phytophthora sojae in soybean.The plant genome · 2021Article
- Evolution ofFrontiers in plant science · 2021Article
- The large repertoire of conifer NLR resistance genes includes drought responsive and highly diversified RNLs.Scientific reports · 2019Article
- Genome- Wide Analysis of the Nucleotide Binding Site Leucine-Rich Repeat Genes of Four Orchids Revealed Extremely Low Numbers of Disease Resistance Genes.Frontiers in genetics · 2019Article
- Sticking to it: phytopathogen effector molecules may converge on evolutionarily conserved host targets in green plants.Current opinion in plant biology · 2018Review
- Out of Water: The Origin and Early Diversification of PlantPlant physiology · 2018Article
- Manipulation of Bryophyte Hosts by Pathogenic and Symbiotic Microbes.Plant & cell physiology · 2018Review
- Plant STAND P-loop NTPases: a current perspective of genome distribution, evolution, and function : Plant STAND P-loop NTPases: genomic organization, evolution, and molecular mechanism models contribute broadly to plant pathogen defense.Molecular genetics and genomics : MGG · 2018Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to their potential roles in pathogen defense, genes encoding nucleotide-binding site (NBS) domain have been particularly surveyed in many angiosperm genomes. Two typical classes were found: one is the TIR-NBS-LRR (TNL) class and the other is the CC-NBS-LRR (CNL) class. It is seldom known, however, what kind of NBS-encoding genes are mainly present in other plant groups, especially the most ancient groups of land plants, that is, bryophytes. To fill this gap of knowledge, in this study, we mainly focused on two bryophyte species: the moss Physcomitrella patens and the liverwort Marchantia polymorpha, to survey their NBS-encoding genes. Surprisingly, two novel classes of NBS-encoding genes were discovered. The first novel class is identified from the P. patens genome and a typical member of this class has a protein kinase (PK) domain at the N-terminus and a LRR domain at the C-terminus, forming a complete structure of PK-NBS-LRR (PNL), reminiscent of TNL and CNL classes in angiosperms. The second class is found from the liverwort genome and a typical member of this class possesses an α/β-hydrolase domain at the N-terminus and also a LRR domain at the C-terminus (Hydrolase-NBS-LRR, HNL). Analysis on intron positions and phases also confirmed the novelty of HNL and PNL classes, as reflected by their specific intron locations or phase characteristics. Phylogenetic analysis covering all four classes of NBS-encoding genes revealed a closer relationship among the HNL, PNL and TNL classes, suggesting the CNL class having a more divergent status from the others. The presence of specific introns highlights the chimerical structures of HNL, PNL and TNL genes, and implies their possible origin via exon-shuffling during the quick lineage separation processes of early land plants.
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