ArticleFrontiers in psychiatry2012
Imaging-genetics in autism spectrum disorder: advances, translational impact, and future directions.
Article in Frontiers in psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The Intersection of Genetics and Neuroimaging: A Systematic Review of Imaging Genetics in Neurological Disease for Personalized Treatment.Journal of molecular neuroscience : MN · 2025Pooled it
- Hippocampal-prefrontal functional neural networks in a rat model of fragile X syndrome are poorly organized with limited resiliency.Scientific reports · 2025Article
- Case report: Familial case with autism spectrum and bipolar disorder showing a 20q11.21 microduplication includingFrontiers in psychiatry · 2023Article
- Bayesian nonparametric method for genetic dissection of brain activation region.Frontiers in neuroscience · 2023Article
- Genetics of structural and functional brain changes in autism spectrum disorder.Translational psychiatry · 2020Review
- Anomalies in uncinate fasciculus development and social defects in preschoolers with autism spectrum disorder.BMC psychiatry · 2019Article
- The oxytocin receptor gene predicts brain activity during an emotion recognition task in autism.Molecular autism · 2019Article
- Parental Perspectives on Psychiatric Comorbidity in Preschoolers With Autism Spectrum Disorders Receiving Publicly Funded Mental Health Services.Frontiers in psychiatry · 2019Article
- Alterations in the inferior longitudinal fasciculus in autism and associations with visual processing: a diffusion-weighted MRI study.Molecular autism · 2018Article
- Elucidating the neurophysiological underpinnings of autism spectrum disorder: new developments.Journal of neural transmission (Vienna, Austria : 1996) · 2014Review
- Using genetic findings in autism for the development of new pharmaceutical compounds.Psychopharmacology · 2014Review
- Neural processing of intentional biological motion in unaffected siblings of children with autism spectrum disorder: an fMRI study.Brain and cognition · 2013Article
- Autism: metabolism, mitochondria, and the microbiome.Global advances in health and medicine · 2013Article
- Article
- Patterning of regional gene expression in autism: new complexity.Scientific reports · 2013Article
- Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders.Microbial ecology in health and disease · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism Spectrum Disorder (ASD) refers to a group of heterogeneous neurodevelopmental disorders that are unified by impairments in reciprocal social communication and a pattern of inflexible behaviors. Recent genetic advances have resolved some of the complexity of the genetic architecture underlying ASD by identifying several genetic variants that contribute to the disorder. Different etiological pathways associated with ASD may converge through effects on common molecular mechanisms, such as synaptogenesis, neuronal motility, and axonal guidance. Recently, with more sophisticated techniques, neuroimaging, and neuropathological studies have provided some consistency of evidence that altered structure, activity, and connectivity within complex neural networks is present in ASD, compared to typically developing children. The imaging-genetics approach promises to help bridge the gap between genetic variation, resultant biological effects on the brain, and production of complex neuropsychiatric symptoms. Here, we review recent findings from the developing field of imaging-genetics applied to ASD. Studies to date have indicated that relevant risk genes are associated with alterations in circuits that mediate socio-emotional, visuo-spatial, and language processing. Longitudinal studies ideally focused on early development, in conjunction with investigation for gene-gene, and gene-environment interactions may move the promise of imaging-genetics in ASD closer to the clinical domain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.