ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2011
Formulation and in vitro characterization of cefpodoxime proxetil gastroretentive microballoons.
Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Pentoxifylline Loaded Floating Microballoons: Design, Development and Characterization.Journal of pharmaceutics · 2013Article
- Natural gums as sustained release carriers: development of gastroretentive drug delivery system of ziprasidone HCl.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2012Article
- Preparation and evaluation of sustained release microballoons of propranolol.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and the purpose of the studyThe objective of the present work was to improve bioavailability of cepodoxime proxetil through gastroretentive microballoon formulation.
methodsMicroballoons of cefpodoxime proxetil were formulated by solvent evaporation and diffusion method employing hydroxypropylmethyl cellulose (HPMC) and ethyl cellulose (EC) polymers and characterized for particle size, surface morphology, incorporation efficiency, floating behavior, in vitro drug release study and differential scanning calorimetry (DSC).
resultsThe average particle size of formulated microballoons was in the range of 54.23±2.78-95.66±2.19µm. Incorporation efficiencies of over 83.77±0.85% were achieved for the optimized formulations. Most of formulations remained buoyant (having buoyancy percentage maximum of 81.36±1.96%) for more than 12 hrs indicating good floating behavior of microballoons. Higher values of correlation coefficients were obtained with Higuchi's square root of time kinetic treatment heralding diffusion as predominant mechanism of drug release.
conclusionInferences drawn from in vitro studies suggest that microballoons may be potential delivery system for cefpodoxime proxetil with improvement in bioavailability in comparison to conventional dosage forms.
Indexed as
Identifiers
22615637PMC3232075What OpenQuestion holds
Registered trials
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