ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2010
Upregulation of the ERG11 gene in Candida krusei by azoles.
Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Genomic Insights ofOpen forum infectious diseases · 2026Review
- Synthesis of new imidazole-based ionic liquids with antifungal activity againstIranian journal of microbiology · 2023Article
- The A756T Mutation of theFrontiers in veterinary science · 2021Article
- Quantitative analysis of the expression of fluconazole-resistant genes in strains of Candida albicans isolated from elderly people at their admission in an intensive care unit in Manizales, ColombiaBiomedica : revista del Instituto Nacional de Salud · 2020Article
- Review
- Fluconazole resistance inInfection and drug resistance · 2017Review
- Azole Antifungal Resistance inFrontiers in microbiology · 2016Review
- Evaluation of mRNA Expression Levels of cyp51A and mdr1, Candidate Genes for Voriconazole Resistance in Aspergillus flavus.Jundishapur journal of microbiology · 2015Article
- Candida parapsilosis Resistance to Fluconazole: Molecular Mechanisms and In Vivo Impact in Infected Galleria mellonella Larvae.Antimicrobial agents and chemotherapy · 2015Article
- Synergistic Interactions of Eugenol-tosylate and Its Congeners with Fluconazole against Candida albicans.PloS one · 2015Article
- Overexpression of Both ERG11 and ABC2 Genes Might Be Responsible for Itraconazole Resistance in Clinical Isolates of Candida krusei.PloS one · 2015Article
- Overexpression of aldo-keto-reductase in azole-resistant clinical isolates of Candida glabrata determined by cDNA-AFLP.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and the purpose of the studyCandida species are the agents of local and systemic opportunistic infections and have become a major cause of morbidity and mortality in the last few decades. Azole resistance in Candida krusei (C. krusei) species appears to be the result of gene alterations in relation to the ergosterol biosynthesis pathway, as well as efflux pumps. The main objective of this study was to examine the RNA expression of ERG11 in C. krusei which had been identified to be resistance to azoles.
methodsThe ERG11 mRNA expression was investigated in four Iranian clinical isolates of C. krusei, which were resistant to fluconazole and itraconazole by a semiquantitative RT-PCR.
resultsThe mRNA expression levels were observed in all four isolates by this technique. Furthermore, it was found that ERG11 expression levels vary among four representative isolates of C. krusei. Although DNA sequencing revealed no significant genetic alteration in the ERG11 gene, one heterozygous polymorphism was observed in two isolates, but not in others. This polymorphism was found in the third base of codon 313 for Thr (ACT>ACC). MAJOR
conclusionEven though such a polymorphism creates a new Ear1 restriction site, no significant effect was found on the resistance of C. krusei to azoles. RESULTS of this investigation are consistent with previous studies and may provide further evidence for the genetic heterogeneity and complexity of the ergosterol biosynthetic pathway or efflux pumps.
Indexed as
Identifiers
22615628PMC3304355W1860848767What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.