ArticlePLoS pathogens2012
Rates of viral evolution are linked to host geography in bat rabies.
Article in PLoS pathogens, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
64 citing papers in PubMed, 100 citations in OpenAlex.
- Ecological Factors and Host Community Characteristics as Potential Drivers of Bat RNA Virus Spillover.Biology · 2026Article
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- Origin and cross-species transmission of bat coronaviruses in China.Nature communications · 2024Article
- Examining the molecular clock hypothesis for the contemporary evolution of the rabies virus.PLoS pathogens · 2024Article
- Investigating the emergence of a zoonotic virus: phylogenetic analysis of European bat lyssavirus 1 in the UK.Virus evolution · 2024Article
- Global patterns of phylogenetic diversity and transmission of bat coronavirus.Science China. Life sciences · 2023Article
- Revealing the complexity of vampire bat rabies "spillover transmission".Infectious diseases of poverty · 2023Article
- Analyzing the Evolution and Host Adaptation of the Rabies Virus from the Perspective of Codon Usage Bias.Transboundary and emerging diseases · 2023Article
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- Cross-Species Transmission of Bat Coronaviruses in the Americas: Contrasting Patterns between Alphacoronavirus and Betacoronavirus.Microbiology spectrum · 2022Article
- Geographic Distribution of Common Vampire BatPathogens (Basel, Switzerland) · 2022Article
- Divergent Rabies Virus Variant of Probable Bat Origin in 2 Gray Foxes, New Mexico, USA.Emerging infectious diseases · 2022Article
- The Emergence of SARS-CoV-2 Variants of Concern Is Driven by Acceleration of the Substitution Rate.Molecular biology and evolution · 2022Article
- Effects of host and pathogenicity on mutation rates in avian influenza A viruses.Virus evolution · 2022Article
- Puumala Virus Variants Circulating in Forests of Ardennes, France: Ten Years of Genetic Evolution.Pathogens (Basel, Switzerland) · 2021Article
- SARS-CoV-2: Origin, Intermediate Host and Allergenicity Features and Hypotheses.Healthcare (Basel, Switzerland) · 2021Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Rates of evolution span orders of magnitude among RNA viruses with important implications for viral transmission and emergence. Although the tempo of viral evolution is often ascribed to viral features such as mutation rates and transmission mode, these factors alone cannot explain variation among closely related viruses, where host biology might operate more strongly on viral evolution. Here, we analyzed sequence data from hundreds of rabies viruses collected from bats throughout the Americas to describe dramatic variation in the speed of rabies virus evolution when circulating in ecologically distinct reservoir species. Integration of ecological and genetic data through a comparative bayesian analysis revealed that viral evolutionary rates were labile following historical jumps between bat species and nearly four times faster in tropical and subtropical bats compared to temperate species. The association between geography and viral evolution could not be explained by host metabolism, phylogeny or variable selection pressures, and instead appeared to be a consequence of reduced seasonality in bat activity and virus transmission associated with climate. Our results demonstrate a key role for host ecology in shaping the tempo of evolution in multi-host viruses and highlight the power of comparative phylogenetic methods to identify the host and environmental features that influence transmission dynamics.
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