ArticleThe Journal of physiology2012
An analysis of deformation-dependent electromechanical coupling in the mouse heart.
Article in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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Who cites it
39 citing papers in PubMed.
- The functional impact of myofiber macroscopic organization and disarray in computational models of the murine heart.PLoS computational biology · 2026Article
- Cell to whole organ global sensitivity analysis on a four-chamber heart electromechanics model using Gaussian processes emulators.PLoS computational biology · 2023Article
- Multiscale characterization of left ventricle active behavior in the mouse.Acta biomaterialia · 2023Article
- Quantitative mapping of force-pCa curves to whole-heart contraction and relaxation.The Journal of physiology · 2022Article
- An accurate, robust, and efficient finite element framework with applications to anisotropic, nearly and fully incompressible elasticity.Computer methods in applied mechanics and engineering · 2022Article
- An Integrated Workflow for Building Digital Twins of Cardiac Electromechanics-A Multi-Fidelity Approach for Personalising Active Mechanics.Mathematics (Basel, Switzerland) · 2022Article
- Cardiac electro-mechanical activity in a deforming human cardiac tissue: modeling, existence-uniqueness, finite element computation and application to multiple ischemic disease.Journal of mathematical biology · 2022Article
- In silico identification of potential calcium dynamics and sarcomere targets for recovering left ventricular function in rat heart failure with preserved ejection fraction.PLoS computational biology · 2021Article
- A mathematical model of hiPSC cardiomyocytes electromechanics.Physiological reports · 2021Article
- In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment.Progress in biophysics and molecular biology · 2021Article
- Active Force Generation in Cardiac Muscle Cells: Mathematical Modeling and Numerical Simulation of the Actin-Myosin Interaction.Vietnam journal of mathematics · 2021Review
- Biophysically detailed mathematical models of multiscale cardiac active mechanics.PLoS computational biology · 2020Article
- Predicting left ventricular contractile function via Gaussian process emulation in aortic-banded rats.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
- Balance of Active, Passive, and Anatomical Cardiac Properties in Doxorubicin-Induced Heart Failure.Biophysical journal · 2019Article
- A short history of the development of mathematical models of cardiac mechanics.Journal of molecular and cellular cardiology · 2019Review
- A Numerical Study of Scalable Cardiac Electro-Mechanical Solvers on HPC Architectures.Frontiers in physiology · 2018Article
- Evaluation of a Novel Finite Element Model of Active Contraction in the Heart.Frontiers in physiology · 2018Article
- Decreasing Compensatory Ability of Concentric Ventricular Hypertrophy in Aortic-Banded Rat Hearts.Frontiers in physiology · 2018Article
- Improved identifiability of myocardial material parameters by an energy-based cost function.Biomechanics and modeling in mechanobiology · 2017Article
- Cardiac kinematic parameters computed from video of in situ beating heart.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
To investigate the effects of the coupling between excitation and contraction on whole-organ function, we have developed a novel biophysically based multiscale electromechanical model of the murine heart. Through comparison with a comprehensive in vivo experimental data set, we show good agreement with pressure and volume measurements at both physiological temperatures and physiological pacing frequencies. This whole-organ model was used to investigate the effects of material and haemodynamic properties introduced at the tissue level, as well as emergent function of our novel cell contraction model. Through a comprehensive sensitivity analysis at both the cellular and whole organ level, we demonstrate the sensitivity of the model's results to its parameters and the constraining effect of experimental data. These results demonstrate the fundamental importance of length- and velocity-dependent feedback to the cellular scale for whole-organ function, and we show that a strong velocity dependence of tension is essential for explaining the differences between measured single cell tension and whole-organ pressure transients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.